Endovascular photodynamic therapy using mono-L-aspartyl-chlorin e6 to inhibit Intimal hyperplasia in balloon-injured rabbit arteries

Lasers in Surgery and Medicine
T NagaeS Ishimaru

Abstract

Intimal hyperplasia (IH) leading to restenosis is a major complication of arterial revascularization. The purpose of this study was to investigate the effect of photodynamic therapy (PDT) using mono-L-aspartyl chlorin e6 (NPe6) as a photosensitizer and intraluminal radial irradiation for inhibition of IH experimentally. Study of laser transmission through the blood indicated that exclusion of blood is a prerequisite for intraluminal PDT. For homogeneous radial laser irradiation to the vessel wall, we used a newly developed cylindrical diffusing balloon laser fiber. Injuries were induced by pulling a balloon catheter through the right iliac artery of rabbits. One and 6 hours after the NPe6 injection (5mg/kg i.v.), drug distribution was examined by fluorescence microscopy. Nineteen rabbits received NPe6 at the time of injuries and PDT was performed with 664-nm laser at 30 and 10 J/cm(2) (20, 30, 40 mW/cm(2)) 1 hour after the injuries. The arteries were harvested at 2 days. In a second group of rabbits, PDT was given at 30 mW/cm(2) (30 J/cm(2)). Two weeks after treatment, the arteries were removed and examined histologically. NPe6 was found to be distributed selectively in the injured media. Endovascular NPe6-PDT showed complete d...Continue Reading

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Citations

Jan 16, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Magdalena WawrzyńskaLeon Strzadała
May 26, 2009·JACC. Cardiovascular Interventions·Yoriyasu SuzukiFumiaki Ikeno
Mar 2, 2006·Toxicologic Pathology·Arturo G Touchard, Robert S Schwartz
Aug 14, 2012·Expert Review of Clinical Immunology·Ying-Ying HuangMichael R Hamblin
Jul 16, 2004·Annals of Vascular Surgery·Norio UchimuraIan L Gordon
Oct 7, 2004·Journal of the American College of Cardiology·Robert S SchwartzRenu Virmani
Aug 30, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M PaiJ McEwan
Nov 29, 2016·Cardiovascular Therapeutics·Manish JainMarie-Noelle Giraud
Mar 30, 2018·Lasers in Medical Science·Jih-Shyong LinWen-Tyng Li

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