Endovascular treatment in older adults with acute ischemic stroke in the MR CLEAN Registry

Neurology
Adrien E GrootMR CLEAN Registry Investigators

Abstract

To explore clinical outcomes in older adults with acute ischemic stroke treated with endovascular thrombectomy (EVT). We included consecutive patients (2014-2016) with an anterior circulation occlusion undergoing EVT from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) Registry. We assessed the effect of age (dichotomized at ≥80 years and as continuous variable) on the modified Rankin Scale (mRS) score at 90 days, symptomatic intracranial hemorrhage (sICH), and reperfusion rate. The association between age and mRS was assessed with multivariable ordinal logistic regression, and a multiplicative interaction term was added to the model to assess modification of reperfusion by age on outcome. Of the 1,526 patients, 380 (25%) were ≥80 years of age (referred to here as older adults). Older adults had a worse functional outcome than younger patients (adjusted common odds ratio [acOR] for an mRS score shift toward better outcome 0.31, 95% confidence interval [CI] 0.24-0.39). Mortality was also higher in older adults (51% vs 22%, adjusted odds ratio 3.12, 95% CI 2.33-4.19). There were no differences in proportion of patients with mRS scores of 4 to 5, sICH, or ...Continue Reading

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Citations

Jun 13, 2020·Neurology·Luciano A Sposato, Svetlana Lorenzano
Mar 26, 2021·Frontiers in Neurology·Shuichi SuzukiMark Fisher
Mar 10, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Laurent DerexAlexandre Y Poppe
May 5, 2021·Der Nervenarzt·Steffen Tiedt, Franziska Dorn
Jul 9, 2021·Stroke; a Journal of Cerebral Circulation·Maria Bres-BullrichLuciano A Sposato
Aug 11, 2021·Journal of the American Geriatrics Society·Justine SudreChristian Denier
Dec 31, 2021·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Yen-Jun LaiChih-Wei Tang

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