Endovascular treatment of experimental aneurysms with use of fibroblast transfected with replication-deficient adenovirus containing bone morphogenetic protein-13 gene

AJNR. American Journal of Neuroradiology
D DaiD F Kallmes

Abstract

Modified coils have failed to improve long-term recanalization of aneurysms. This study examined whether ex vivo transduction of replication-deficient adenovirus containing the bone morphogenetic protein-13 gene (Ad-BMP-13) in fibroblast allografts would improve angiographic results via increased collagen synthesis, compared with fibroblast-coated platinum coils (FBC) and bare platinum coils (PA). Aneurysms were embolized with Ad-BMP-13-coated coils (n = 20). Rabbits were sacrificed at 14 days and at 1, 3, and 6 months after implantation. Digital subtraction angiography (DSA) evaluated stability after embolization. Histologic specimens were examined with a qualitative grading system. Masson trichrome evaluated collagen deposition. Findings were compared with previously reported controls for PA and FBC in the same model and time points. The grading system showed a greater total score (P = .0002) in Ad-BMP-13 (6.8 +/- 1.6) and FBC (6.3 +/- 2.4) compared with PA (4.7 +/- 2.4). A group main effects test showed that aneurysm neck tissue coverage in Ad-BMP-13 (2.5 +/- 1.1) was higher (P = .0007) than both FBC (1.6 +/- 1.4) and PA (0.9 +/- 1.1). Ad-BMP-13 had more (P < .0001) collagen deposition than the FBC and PA. One- and 3-month A...Continue Reading

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Citations

Mar 16, 2011·Journal of Biomedicine & Biotechnology·Carlos ZaragozaJesus Egido
Jan 25, 2014·Biologicals : Journal of the International Association of Biological Standardization·Lisa A WilliamsAshish D Diwan
Jul 17, 2010·AJNR. American Journal of Neuroradiology·Y DingD F Kallmes
Feb 19, 2011·AJNR. American Journal of Neuroradiology·Y H DingD F Kallmes
Apr 13, 2011·Journal of Vascular and Interventional Radiology : JVIR·Ramanathan KadirvelDavid F Kallmes
Nov 29, 2014·AJNR. American Journal of Neuroradiology·W BrinjikjiR Kadirvel
Mar 8, 2005·Journal of Pediatric Surgery·C Jason SmithersSteven J Fishman
Aug 5, 2017·Journal of Neurointerventional Surgery·Shunli WangDavid F Kallmes
Oct 23, 2010·AJNR. American Journal of Neuroradiology·C SherifJ Fandino
Jun 7, 2019·Advanced Materials·Jingjie HuRahmi Oklu
Aug 21, 2020·AJNR. American Journal of Neuroradiology·Z KhashimR Kadirvel
Nov 20, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Basil E GrüterSerge Marbacher

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