PMID: 6973006Mar 1, 1981Paper

Endplate channel block by guanidine derivatives

The Journal of General Physiology
J M FarleyT Narahashi

Abstract

The effects of the n-alkyl derivatives of guanidine on the frog neuromuscular junction were studied using the two-microelectrode voltage clamp and other electrophysiological techniques. Methyl-, ethyl-, and propylguanidine stimulated the nerve-evoked release of transmitter. However, amyl-and octylguanidine had no apparent presynaptic action. All of the derivatives blocked the postsynaptic response to acetylcholine, the potency sequence being octyl-greater than amyl-greater than propyl-, methyl-greater than ethylguanidine. Methyl- and octylguanidine did not protect the receptor from alpha-bungarotoxin block, suggesting that these compounds do not bind to the receptor but probably block the ionic channel. Methyl-, ethyl-, and propylguanidine shortened inward endplate currents but prolonged outward currents. Amylguanidine prolonged both inward and outward endplate currents, and the currents became biphasic at negative membrane potentials. Octylguanidine increased the rate of decay of endplate currents at all potentials. All of the derivatives blocked inward endplate currents more markedly than outward currents, resulting in a highly nonlinear current-voltage relation. Methyl-, ethyl-, and propylguanidine reversed the voltage depen...Continue Reading

References

Sep 1, 1975·Experimental Neurology·H Teräväinen, A Larsen
Jan 1, 1979·Neuroscience·J M FarleyT Narahashi
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M AdlerE X Albuquerque
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P R Adams, B Sakmann
Sep 1, 1978·The Journal of General Physiology·L M Masukawa, E X Albuquerque
Jul 1, 1979·Archives of Biochemistry and Biophysics·J K Reed, W Trzos
Mar 1, 1974·European Journal of Pharmacology·M M Goldner, T Narahashi
Jan 1, 1970·Journal of Neurobiology·K Kusano
Sep 1, 1980·The Journal of General Physiology·G E KirschT Narahashi
May 1, 1964·The Journal of General Physiology·T NARAHASHIW R SCOTT

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Citations

Mar 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·K A Alkadhi
Jun 1, 1986·Pflügers Archiv : European journal of physiology·J M FarleyT Narahashi
Dec 9, 1985·Brain Research·K Enomoto, C Edwards
Nov 5, 1985·European Journal of Pharmacology·K EnomotoC Edwards
Nov 4, 1986·European Journal of Pharmacology·K MasuoT Maeno
Jun 19, 1987·European Journal of Pharmacology·K A Alkadhi
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·J C de Freitas, M I Sawaya
Jan 1, 1988·Pharmacology & Therapeutics·F J Barrantes
Dec 1, 1981·The Journal of General Physiology·D J AdamsB Hille
Jun 1, 1984·The Journal of General Physiology·S M VogelT Narahashi
Sep 1, 1984·The Journal of General Physiology·D Yamamoto, J Z Yeh
Jun 1, 1986·The Journal of General Physiology·J A SanchezB Hille
Jul 1, 1984·British Journal of Pharmacology·W D AtchisonS M Vogel
Sep 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·K TakedaP W Gage
Jan 1, 1984·Annals of Neurology·T Narahashi
Mar 1, 1984·British Journal of Pharmacology·H P Rang, R J Rylett

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