Endplate Defect Is Heritable, Associated With Low Back Pain and Triggers Intervertebral Disc Degeneration: A Longitudinal Study From TwinsUK

Spine
Sabrina MunirFrances M K Williams

Abstract

Longitudinal study of spine magnetic resonance imaging (MRI) in a large-scale population-based study. To determine the order of appearance of degenerative change in vertebral bodies and intervertebral discs. We also sought to define the influence of endplate defect on low back pain (LBP) and to determine whether there is a genetic influence on endplate defect. Endplate defect is a magnetic resonance imaging trait, found to be associated with intervertebral disc degeneration. There is a lack of understanding regarding the mechanism underlying lumbar disc degeneration (LDD). Recent attention has shifted to vertebral endplate defects and their role in spine degeneration pathology. Individuals from the TwinsUK spine study having longitudinal T2-weighted lumbar MR scans at baseline (n = 996) and a decade later (n = 438) were included. LDD, vertebral endplate defect by calculating a total endplate score, and Modic change (MC) were assessed using standard techniques. Mixed-effects models were used to determine the association between the features of spine pathology, adjusted for covariates. Endplate defect heritability was estimated using variance component analysis. Significant association was found between endplate defect, LDD, MRI ...Continue Reading

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Citations

Oct 19, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Yu N Sorokin
May 27, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jeffrey S FischgrundMichael Sikorsky
Jan 25, 2020·The Journal of Sports Medicine and Physical Fitness·Ulrika Aasa, Lars Berglund
Mar 29, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Aliyu LawanMichele C Battié
Dec 1, 2020·Global Spine Journal·G Michael MallowDino Samartzis
Sep 6, 2020·Clinical Neurology and Neurosurgery·Murat Şakir EkşiM Necmettin Pamir
Feb 18, 2020·Medical Hypotheses·Tanja BatinacIgor Barković
Jan 16, 2021·International Journal of Molecular Sciences·Laura BaumgartnerJérôme Noailly
Mar 12, 2021·Spine·Modarress JulinJaro Karppinen
Mar 23, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·James D BakerDino Samartzis
May 23, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Aliyu LawanMichele C Battié
Jul 27, 2021·Journal of Magnetic Resonance Imaging : JMRI·Rahman Ud DinHaisheng Yang

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