Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice

Journal of Diabetes Research
Cornelia MardareFrank-Christoph Mooren

Abstract

The study aimed to investigate the effects of differentiated exercise regimes on high fat-induced metabolic and inflammatory pathways. Mice were fed a standard diet (ST) or a high fat diet (HFD) and subjected to regular endurance training (ET) or resistance training (RT). After 10 weeks body weight, glucose tolerance, fatty acids (FAs), circulating ceramides, cytokines, and immunological mediators were determined. The HFD induced a significant increase in body weight and a disturbed glucose tolerance (p < 0.05). An increase of plasma FA, ceramides, and inflammatory mediators in adipose tissue and serum was found (p < 0.05). Both endurance and resistance training decreased body weight (p < 0.05) and reduced serum ceramides (p < 0.005). While RT attenuated the increase of NLRP-3 (RT) expression in adipose tissue, ET was effective in reducing TNF-α and IL-18 expression. Furthermore, ET reduced levels of MIP-1γ, while RT decreased levels of IL-18, MIP-1γ, Timp-1, and CD40 in serum (p < 0.001), respectively. Although both exercise regimes improved glucose tolerance (p < 0.001), ET was more effective than RT. These results suggest that exercise improves HFD-induced complications possibly through a reduction of ceramides, the reductio...Continue Reading

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Citations

Apr 14, 2016·Journal of Diabetes Research·Martin RöhlingKarsten Müssig
Jul 26, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Mohammed Andaleeb ChowdhuryLijun C Liu
Aug 2, 2019·Annals of Clinical and Translational Neurology·Nina FainsteinOfira Einstein
Jun 5, 2019·Journal of Cardiovascular Translational Research·Akehu AlemasiWei Gao
Dec 30, 2020·International Journal of Molecular Sciences·José Cesar Rosa-Neto, Loreana Sanches Silveira

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Methods Mentioned

BETA
PCR
ELISA
electrophoresis

Software Mentioned

GeNorm
Rotorgene

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