Endurance exercise activates matrix metalloproteinases in human skeletal muscle

Journal of Applied Physiology
E RullmanT Gustafsson

Abstract

In the present study, the effect of exercise training on the expression and activity of matrix metalloproteinases (MMPs) in the human skeletal muscle was investigated. Ten subjects exercised one leg for 45 min with restricted blood flow and then exercised the other leg at the same absolute workload with unrestricted blood flow. The exercises were conducted four times per week for 5 wk. Biopsies were taken from the vastus lateralis muscles of both legs at rest before the training period, after 10 days and 5 wk of training, and 2 h after the first exercise bout for analysis of MMP and tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA, enzyme activity, and protein expression. Levels of MMP-2, MMP-14, and TIMP-1 mRNA in muscle tissue increased after 10 days of training regardless of blood flow condition. MMP-2 mRNA level in laser-dissected myofibers and MMP-2 activity in whole muscle increased with training. The level of MMP-9 mRNA and activity increased after the first bout of exercise. Although MMP-9 mRNA levels appeared to be very low, the activity of MMP-9 after a single bout of exercise was similar to that of MMP-2 after 10 days of exercise. MMP-2 and MMP-9 protein was both present throughout the extracellular matrix of th...Continue Reading

References

Jan 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C W Guérin, P C Holland
Jul 1, 1993·Acta Physiologica Scandinavica·M EsbjörnssonL Kaijser
Jan 1, 1995·Advances in Experimental Medicine and Biology·H Bjurstedt, O Eiken
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T L HaasO Hudlicka
Feb 22, 2001·Journal of Applied Physiology·D Pette
Mar 27, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D M RoachP A Cowled
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Irina RivilisTara L Haas
May 24, 2003·American Journal of Physiology. Heart and Circulatory Physiology·N HiscockB K Pedersen
Apr 9, 2004·Biology of Reproduction·Hedley A CoppockMelissa Westwood
Jul 31, 2004·Clinical Science·Ruksana HudaMali Mathru
Apr 7, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Helene AmelnYuichi Makino
May 17, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Malgorzata Milkiewicz, Tara L Haas
May 25, 2005·The Journal of Cell Biology·Sunyoung LeeM Luisa Iruela-Arispe
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Dec 15, 2006·Journal of Cellular Physiology·Chunhong Yan, Douglas D Boyd
Jan 27, 2007·Journal of Applied Physiology·E RullmanT Gustafsson
Jun 16, 2007·Journal of Basic and Clinical Physiology and Pharmacology·Eli CarmeliE Carlos Nemcovsky
Jun 16, 2007·Journal of Applied Physiology·T GustafssonC J Sundberg
Mar 4, 2008·The International Journal of Developmental Biology·Malgorzata ZimowskaJerzy Moraczewski

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Citations

Jan 12, 2011·European Journal of Applied Physiology·Molly C MaddenDavid L Allen
Nov 20, 2012·European Journal of Applied Physiology·E RullmanT Gustafsson
Apr 9, 2011·Biotechnology Letters·S PasseyM P Lewis
Nov 8, 2013·Journal of Translational Medicine·Marianna BellafioreAntonio Paoli
Sep 22, 2010·Journal of Basic and Clinical Physiology and Pharmacology·Eli CarmeliEinat Kodesh
Jun 14, 2014·Canadian Journal of Physiology and Pharmacology·Lee WinchesterSuresh C Tyagi
Jun 7, 2014·Journal of Cellular Physiology·Elin Hadler-OlsenLars Uhlin-Hansen
Feb 4, 2016·Sports Medicine·Eduardo Teixeira, José Alberto Duarte
Apr 16, 2015·Oxidative Medicine and Cellular Longevity·Anikó PósaCsaba Varga
Mar 13, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jianying ZhangJames H-C Wang
May 19, 2012·Scandinavian Journal of Immunology·D ReihmaneP Tretjakovs
Mar 23, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·I Mark Olfert, Olivier Birot
Nov 12, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tara L Haas, Emmanuel Nwadozi
Nov 23, 2011·Biochemical Society Transactions·Thomas Gustafsson
Aug 14, 2012·Neurobiology of Disease·Hala S Alameddine
May 31, 2015·Journal of Muscle Research and Cell Motility·C Snyman, C U Niesler
Sep 26, 2014·Sports Medicine·Dahan da Cunha NascimentoJonato Prestes
Sep 13, 2014·Histochemistry and Cell Biology·Marine YeghiazaryanGrzegorz M Wilczyński
Oct 9, 2015·PloS One·Sarah Ilkhanipour RooneyLouis J Soslowsky
Apr 23, 2016·The Journal of Physiology·Melissa A LindenR Scott Rector
Dec 20, 2013·Expert Review of Proteomics·Dayle L SampsonTony J Parker
Dec 13, 2016·Pharmaceutical Biology·Mohammad ZamanianMohammad Allahtavakoli
Jul 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Oliver Baum, Marius Bigler
Nov 3, 2016·Journal of Applied Physiology·Koyal Garg, Marni D Boppart
Feb 20, 2019·American Journal of Physiology. Endocrinology and Metabolism·Pernille HojmanBente Klarlund Pedersen
Jun 11, 2019·Journal of Cellular Physiology·Kathryn W Aguilar-AgonMark P Lewis
Mar 30, 2018·Physiological Reports·Lee J WinchesterSuresh C Tyagi
May 4, 2013·Journal of Applied Physiology·Max E DavisChristopher L Mendias
Dec 19, 2013·Medicine and Science in Sports and Exercise·Mark D RossMichael Harrison
Nov 22, 2014·Physiological Reports·Riki OgasawaraSatoshi Fujita
May 19, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shivam H PatelChad C Carroll
Jun 29, 2018·European Journal of Applied Physiology·Patrik SundbladThomas Gustafsson

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