Endurance exercise performance in acute hypoxia is influenced by expiratory flow limitation

European Journal of Applied Physiology
Joshua C WeavilTimothy D Mickleborough

Abstract

We sought to determine if expiratory flow limitation influences intensive aerobic exercise performance in mild hypoxia. Fourteen trained male cyclists were separated into flow-limited (FL, n = 7) and non-FL (n = 7) groups based on the extent of expiratory flow limitation exhibited during maximal exercise in normoxia. Participants performed two self-paced 5-km cycling time trials, one in normoxic (F IO2 = 0.21) and one in mild hypoxic (F IO2 = 0.17) conditions in a randomized, balanced order with the subjects blinded to composition of the inspirate. Percent change from normoxia to hypoxia in average power output (%ΔP TT) and time to completion (%ΔT TT) were used to assess performance. Hypoxia resulted in a significant decline in estimated arterial O2 saturation and decrements in performance in both groups, although FL had a significantly smaller %ΔP TT (-4.0 ± 0.5 vs. -9.0 ± 1.8 %) and %ΔT TT (1.3 ± 0.3 vs. 3.7 ± 0.9 %) compared to non-FL. At the 5th km of the time trial, minute ventilation did not change from normoxia to hypoxia in FL (3.4 ± 3.1 %) or non-FL (2.3 ± 3.7 %), but only the non-FL reported a significantly increased dyspnea rating in hypoxia compared to normoxia (~9 %). Non-FL athletes did not utilize their ventilato...Continue Reading

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Citations

Nov 3, 2016·The Physician and Sportsmedicine·Ren-Jay SheiTimothy D Mickleborough
Mar 25, 2020·Physiological Reports·Elizabeth A GideonJoseph W Duke
Feb 27, 2020·Medicine and Science in Sports and Exercise·Katherine R CoxStephanie P Kurti
Mar 18, 2016·The Cochrane Database of Systematic Reviews·Nipun ShresthaSoumyadeep Bhaumik
Jun 6, 2019·European Journal of Sport Science·Jessica A FreemasTimothy D Mickleborough
Dec 2, 2017·Experimental Physiology·Joseph W DukeAndrew T Lovering
Jul 3, 2021·Frontiers in Physiology·Kamila PłoszczycaMarcin Baranowski

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