PMID: 8964732Mar 1, 1996Paper

Endurance exercise training decreases capillary basement membrane width in older nondiabetic and diabetic adults

Journal of Applied Physiology
J R WilliamsonO Holloszy

Abstract

The objectives of these studies were to 1) evaluate the relationships among age, glucose intolerance, and skeletal muscle capillary basement membrane (CBM) width (CBMW) and 2) determine the effects of exercise training on CBMW by comparing values of young (28 +/- 4 yr) and older (63 +/- 7 yr) athletes with those of age-matched sedentary control subjects and by measuring CBMW in older men and women before and after a 9-mo endurance-exercise training program. CBMW was measured in tissue samples obtained from the gastrocnemius muscle. CBMW in sedentary 64 +/- 3-yr-old subjects was 25% thicker than in sedentary 24 +/- 3-yr-old subjects. CBMW was similar in young and older athletes and was thinner than the CBMW of age-matched sedentary control subjects. There were no differences in CBMW among older sedentary individuals with normal or impaired glucose tolerance or mild non-insulin-dependent diabetes mellitus. Nine months of endurance exercise training reduced CBMW in older men and women by 30-40%, to widths that were not different from those of the young subjects; this response was independent of glucose tolerance status. These findings suggest that habitual exercise prevents the thickening of the skeletal muscle CBM that is charact...Continue Reading

Citations

Nov 29, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Wildor HollmannGerard King
Jun 16, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·William J DurhamMelinda Sheffield-Moore
Nov 30, 2018·Medicine and Science in Sports and Exercise·David M HurleyJill M Slade
Apr 13, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Florence T H WuAleksander S Popel
Nov 15, 2018·Physiological Reviews·Lars LarssonMarco Sandri
Nov 27, 2015·American Journal of Physiology. Heart and Circulatory Physiology·I Mark OlfertStuart Egginton
Nov 13, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Gianni PariseMichael J Plyley
Mar 25, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Oliver BaumYlva Hellsten
Nov 28, 2018·Scandinavian Journal of Medicine & Science in Sports·Stefan Peter MortensenOliver Baum
Nov 22, 2015·Scandinavian Journal of Medicine & Science in Sports·M NybergY Hellsten
Jul 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Oliver Baum, Marius Bigler
Jan 6, 2015·Developmental Biology·Alice P ChristensenSuzannah A Williams
Jun 7, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Celena Scheede-BergdahlFlemming Dela
Aug 14, 2021·Cardiovascular Endocrinology & Metabolism·Fred J DiMenna, Avigdor D Arad

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