Endurance exercise training does not limit coronary atherosclerosis in familial hypercholesterolemic swine

Physiological Reports
Darla L TharpDouglas K Bowles

Abstract

Human studies demonstrate that physical activity reduces both morbidity and mortality of coronary heart disease (CHD) including decreased progression and/or regression of CHD with life-style modification which includes exercise. However, evidence supporting an intrinsic, direct effect of exercise in attenuating the development of CHD is equivocal. One limitation has been the lack of a large animal model with clinically evident CHD disease. Thus, we examined the role of endurance exercise in CHD development in a swine model of familial hypercholesterolemia (FH) that exhibits robust, complex atherosclerosis. FH swine were randomly assigned to either sedentary (Sed) or exercise trained (Ex) groups. At 10 months of age, Ex pigs began a 10 months, moderate-intensity treadmill-training intervention. At 14 months, all pigs were switched to a high-fat, high-cholesterol diet. CHD was assessed by intravascular ultrasound (IVUS) both prior to and after completion of 6 months on the HFC diet. Prior to HFC diet, Ex resulted in a greater coronary artery size in the proximal and mid sections of the LCX compared to SED, with no effect in the LAD. After 6 months on HFC diet, there was a 5-6 fold increase in absolute plaque volume in all segment...Continue Reading

References

Oct 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H L Wyatt, J Mitchell
May 28, 1987·The New England Journal of Medicine·S GlagovG J Kolettis
Jan 1, 1972·Advances in Experimental Medicine and Biology·R P LinkA H Safanie
Jan 1, 1972·Atherosclerosis·R P LinkA H Safanie
Dec 17, 1981·The New England Journal of Medicine·D M KramschW B Hood
Apr 1, 1993·Circulation·W L HaskellE L Alderman
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Stephan WindeckerChristian Seiler
Nov 13, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·James R Turk, M Harold Laughlin
Mar 3, 2005·Medicine and Science in Sports and Exercise·Donna H KorzickDouglas K Bowles
Jun 29, 2005·Circulation·Peter Libby, Pierre Theroux
Feb 28, 2007·American Journal of Hypertension·Michaela KozakovaCarlo Palombo
Jun 2, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Vyacheslav A KorshunovBradford C Berk
Jun 6, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Francesco SofiGian Franco Gensini
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Bradley S Fleenor, Douglas K Bowles
Mar 20, 2010·Journal of Applied Physiology·Xin LongMichael Sturek
Jun 21, 2011·Medicine and Science in Sports and Exercise·Arturo A Arce-EsquivelM Harold Laughlin
Aug 26, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kyle S McCommisChristopher P Baines
Oct 11, 2011·American Journal of Physiology. Heart and Circulatory Physiology·M Harold LaughlinDirk J Duncker
Jul 11, 2012·Medicine and Science in Sports and Exercise·Isabelle MasseauDouglas K Bowles
Oct 26, 2013·Journal of Applied Physiology·Vincent J de BeerM Harold Laughlin
Jan 5, 2014·Circulation Research·Carlos Silvestre-RoigOliver Soehnlein
Aug 19, 2014·Ultrasound in Medicine & Biology·Joseph P KilroyJohn A Hossack
Dec 3, 2014·Progress in Cardiovascular Diseases·Rebecca S Bruning, Michael Sturek
Apr 22, 2015·Annals of Biomedical Engineering·Joseph P KilroyJohn A Hossack
Jul 12, 2017·International Journal of Circumpolar Health·Manpreet Saini
Aug 18, 2017·Physiological Reviews·Frank W BoothRyan G Toedebusch
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee

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Mar 21, 2020·American Journal of Physiology. Heart and Circulatory Physiology·David C PooleTimothy I Musch

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