Endurance performance in humans: the effect of a dopamine precursor or a specific serotonin (5-HT2A/2C) antagonist

International Journal of Sports Medicine
Romain MeeusenK De Meirleir

Abstract

In this study we examined the effect of a dopamine (DA) precursor (L-DOPA) or a serotonin (5-HT) antagonist (Ritanserin) on time to exhaustion. The study had a double-blind, randomised, placebo controlled and cross-over design. Seven moderately trained men performed three tests to exhaustion at 65% Wattmax. Each test was separated by two weeks to allow washout of the drugs (dose: 4 mg/kg Sinemet, and 0.3 mg/kg Ritanserin). Blood lactate, hematocrit, glucose, ammonia, free fatty acids (FFA), growth hormone (GH) and catecholamines were determined before and after exercise. Time to exhaustion did not differ between the three trials. Most of the parameters measured in this study responded as predicted during cycling to exhaustion in man. DA agonism significantly increased heart rate, lactate, and plasma DA values at rest, while other parameters such as FFA, lactate, plasma noradrenaline (NA) and adrenaline (A), and plasma GH showed the highest absolute levels at exhaustion. Ritanserin did not influence basal glucose and heart rate at rest, but this group showed a much lower increase in plasma catecholamine levels. We conclude that under the present conditions, neither a metabolic precursor of DA nor a specific centrally acting 5-HT...Continue Reading

Citations

Jun 13, 2006·Journal of Sports Sciences·Romain MeeusenJiri Dvorak
Mar 25, 2004·British Journal of Sports Medicine·M F PiacentiniK De Meirleir
Jun 18, 2009·European Journal of Applied Physiology·Bart RoelandsRomain Meeusen
Feb 16, 2008·Neuromolecular Medicine·Teresa E Foley, Monika Fleshner
Oct 20, 2007·The Journal of Physiology·Hiroshi HasegawaRomain Meeusen
Sep 15, 2015·Life Sciences·Jiexiu ZhaoSantiago Lorenzo
Apr 15, 2008·Medicine and Science in Sports and Exercise·Bart RoelandsRomain R Meeusen
May 28, 2005·Journal of Applied Physiology·Hiroshi HasegawaYvette Michotte
Mar 3, 2005·Medicine and Science in Sports and Exercise·Arthur T StrachanRonald J Maughan
Oct 16, 2015·Medicine and Science in Sports and Exercise·Philip CorderyPhillip Watson
Jul 20, 2002·Medicine and Science in Sports and Exercise·Maria Francesca PiacentiniKenny De Meirleir
Mar 21, 2017·European Journal of Sport Science·Romain Meeusen, Bart Roelands
Nov 17, 2005·The International Journal of Neuroscience·Young-Ja JeongChae-Moon Suh
Sep 29, 2006·Sports Medicine·Romain MeeusenMaria F Piacentini
Jul 11, 2020·International Journal of Tryptophan Research : IJTR·Masatoshi Yamashita
Jul 28, 2016·Journal of Molecular Neuroscience : MN·Christina J Perry

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