PMID: 6401405Jan 1, 1983Paper

Endurance training affects lactate clearance, not lactate production

The American Journal of Physiology
C M Donovan, George A Brooks

Abstract

Primed-continuous infusion of [2-3H]- and [U-14C]lactate was used to study the effects of endurance training (running 2 h/day at 29.4 m/min up a 15% gradient) on lactate metabolism in rats. Measurements were made under three metabolic conditions: rest (Re), easy exercise (EE, 13.4 m/min, 1% gradient) and hard exercise (HE, 26.8 m/min, 1% gradient). Blood lactate levels in trained animals increased from 1.0 +/- 0.09 mM in Re to 1.64 +/- 0.21 in EE and 2.66 +/- 0.38 in HE. Control animals also demonstrated an increase in blood lactate with increasing work rate, but values were 1.93 +/- 0.21 and 4.62 +/- 0.57 mM at EE and HE, respectively. Lactate turnover rates (RtLA) measured with [U-14C]lactate increased from 214.0 +/- 17.0 mumol.kg-1.min-1 in Re to 390.3 +/- 31.6 in EE and 518.1 +/- 56.4 in HE. No significant differences in RtLA were observed between controls and trained animals under any condition. Identical relationships between RtLA and exercise or training were obtained with [2-3H]lactate; however, the values obtained were consistently 90% higher than those observed with [U-14C]lactate. Metabolic clearance rate (MCR) for 14C was not significantly different in Re between controls and trained animals (180.6 +/- 27.7 ml.kg-1....Continue Reading

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Citations

Apr 6, 2000·American Journal of Physiology. Endocrinology and Metabolism·H DubouchaudG A Brooks
Jan 25, 2000·American Journal of Physiology. Endocrinology and Metabolism·H GreenS Grant
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·H GreenJ Ouyang
Aug 17, 2002·Journal of Applied Physiology·Kevin M KelleyL Bruce Gladden
Feb 27, 2003·American Journal of Physiology. Endocrinology and Metabolism·Mark J RoefDirk-Jan Reijngoud
Oct 17, 2002·Journal of Applied Physiology·David R Bassett
Jun 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E de Graaf-RoelfsemaJ H van der Kolk
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew L JohnsonGeorge A Brooks
Apr 27, 2012·American Journal of Physiology. Endocrinology and Metabolism·Kishorchandra Gohil, George A Brooks
Apr 6, 2013·Journal of Applied Physiology·Laurent A MessonnierGeorge A Brooks
Feb 24, 2018·F1000Research·Jens FreeseHelmut Lötzerich
Apr 14, 2018·Frontiers in Physiology·Gernot O HeringJens Stepan
May 3, 2020·The Journal of Physiology·Brian GlancyL Bruce Gladden
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·B C BergmanG A Brooks
Oct 7, 2009·The Journal of Physiology·George A Brooks
Mar 13, 2014·Journal of Applied Physiology·Masaki Takimoto, Taku Hamada
Jan 27, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naoki HoriiMotoyuki Iemitsu
Jun 26, 2020·Frontiers in Physiology·Iñigo San-MillánTravis Nemkov
Mar 15, 2001·Journal of Applied Physiology·K D Sumida, C M Donovan
May 28, 2009·Journal of Applied Physiology·Zinta A ZarinsGeorge A Brooks
Nov 16, 2018·Journal of Human Kinetics·Jean-François DionneFrançois Trudeau
Oct 28, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew L JohnsonGeorge A Brooks
Jun 22, 2013·Journal of Applied Physiology·Chi-An W EmhoffGeorge A Brooks
Mar 16, 2002·Journal of Applied Physiology·Grant B McClelland, George A Brooks
Nov 22, 2001·Journal of Applied Physiology·J J HamannL B Gladden
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Benjamin F MillerGeorge A Brooks
Nov 2, 2002·The Journal of Physiology·Benjamin F MillerGeorge A Brooks
Oct 29, 2020·The Journal of Physiology·David C PooleL Bruce Gladden
May 14, 2021·Frontiers in Physiology·Gernot O Hering, Jens Stepan
May 1, 1992·Pharmacology, Biochemistry, and Behavior·S R BabuS M Somani
Jul 3, 2021·Nature Metabolism·Caroline R BartmanJoshua D Rabinowitz
Dec 6, 2005·The Journal of Experimental Biology·Andrew PhilpPeter W Watt

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