Endurance training increases exercise-induced prostacyclin release in young, healthy men--relationship with VO2max

Pharmacological Reports : PR
J A ZoladzS Chłopicki

Abstract

In the present study, we evaluated the effect of 5 weeks of moderate-intensity endurance training on the basal and exercise-induced systemic release of prostacyclin (PGI(2)), as assessed by plasma 6-keto-PGF(1 alpha) concentration. Twelve physically active young men with the following characteristics participated in this study (the mean +/- SD): age, 22.7 +/- 2.0 years; body mass, 76.8 +/- 8.9 kg; BMI, 23.48 +/- 2.17 kg x m(-2); and maximal oxygen uptake (VO(2 max)), 46.1 +/- 4.0 ml x kg(-1) x min(-1). Plasma 6-keto-PGF(1 alpha) concentrations were measured in venous blood samples taken prior to the exercise and at exhaustion (at VO(2 max)) before and after completing the training protocol. On average, the training resulted in a significant increase in VO(2 max) (p = 0.03), power output at VO(2 max) (p = 0.001) and a significant increase (p = 0.05) in the net-exercise-induced increase in plasma 6-keto-PGF(1 alpha) concentration (Delta 6-keto-PGF(1 alpha) i.e., the difference between the end-exercise and pre-exercise 6-keto-PGF(1 alpha) concentrations). No effect of training on the basal PGI(2) concentration was found. Interestingly, within the study sample (n = 12), two subgroups could be defined with a differential pattern of ...Continue Reading

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Citations

Aug 21, 2012·Neurochemical Research·Jerzy A ZoladzGrzegorz Bartosz
Nov 12, 2015·BioMed Research International·Stefan Heber, Ivo Volf
Sep 1, 2015·Pharmacological Reports : PR·Jerzy A ZoladzStefan Chlopicki
Feb 6, 2017·Physiological Reviews·Daniel J GreenDick H J Thijssen
Mar 9, 2013·Journal of Applied Physiology·Jill N BarnesMichael J Joyner
Dec 5, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·M WojewodaS Chlopicki
Aug 7, 2020·Journal of Clinical Medicine·Gaetano Antonio LanzaMassimo Leggio

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