Enduring attentional deficits in rats treated with a peripheral nerve injury

Behavioural Brain Research
G A HigginsS Thevarkunnel

Abstract

The present study investigated the impact of a spared nerve injury (SNI) on the daily performance of rats tested in two instrumental conditioning procedures: the progressive ratio (PR) schedule of food reinforcement to study motivation for an appetitive stimulus, and the 5-choice serial reaction time task (5-CSRTT), a test of attention and reaction time. Separate groups of male, Sprague-Dawley rats of age 8-10 months were trained to asymptotic performance in either task, before undergoing either SNI or sham surgery. After a recovery period of 3-4 days the animals were run 5 days/week for 3 months in either task. Tests of responsivity to evoked tactile (Von Frey) and thermal (acetone) stimuli were also conducted over this period to check integrity of the model. Post SNI surgery, rats showed equivalent responding to sham controls for food available under a PR schedule throughout the test period, implying a similar level of motivation for a food reward. In contrast, a performance deficit emerged in SNI treated rats run in the 5-CSRTT, consistent with an attentional deficit. This deficit emerged during the second month post-surgery and was characterized by slower response speed, reduced accuracy and increased trial omissions. Both ...Continue Reading

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Citations

May 17, 2018·Frontiers in Pharmacology·Rafael Gonzalez-CanoMichael Costigan
May 15, 2020·International Journal of Molecular Sciences·Francesca GuidaSabatino Maione
Feb 2, 2021·Neuropharmacology·Arbi NazarianThomas J Martin
Jan 30, 2021·Trends in Cognitive Sciences·Caroline E PhelpsFrank Porreca
Sep 28, 2020·Neuroscience and Biobehavioral Reviews·Ana Margarida CunhaHugo Leite-Almeida
May 24, 2021·The Journal of Pain : Official Journal of the American Pain Society·Caroline E PhelpsFrank Porreca
Jan 1, 2020·Neurobiology of Pain·Ana Margarida CunhaHugo Leite-Almeida

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