Enduring effects of environmental enrichment from weaning to adulthood on pituitary-adrenal function, pre-pulse inhibition and learning in male and female rats

Yolanda PeñaRosa M Escorihuela


Environmental enrichment (EE) increases stimulation and provides richer sensory, cognitive and motor opportunities through the interaction with the social and physical environment. EE produces a wide range of neuroanatomical, neurochemical and behavioural effects in several animal species. However, the effects of EE have mainly been studied shortly after the treatment, so its long-lasting effects remain to be elucidated. Thus, we studied in male and female Sprague-Dawley rats the enduring effects of EE on tasks that measured emotional reactivity, social exploration and memory, sensorimotor gating and learning. After weaning, rats reared in EE were housed in single-sex groups of 12-14 in enriched cages during 12 weeks, whereas control rats were housed in single-sex groups of 2-3 animals in standard cages. Then, all rats were housed in pairs and successively exposed to different tests between 4 and 60 weeks post-EE. The results indicated that animals of both sexes reared in EE gained less weight during the enrichment period; differences disappeared in females during the post-EE period, but were maintained intact in males. Rats reared in EE showed an altered daily pattern of corticosterone and a lower hormone response to a novel e...Continue Reading


Jan 7, 1998·Neuroscience and Biobehavioral Reviews·R J Rodgers, A Dalvi
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·J LehmannJ Feldon
Mar 4, 2000·Behavioural Brain Research·A Becker, G Grecksch
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·C RamponY Hu
Dec 28, 2000·Behavioural Brain Research·J LehmannJ Feldon
Jun 19, 2001·Anais Da Academia Brasileira De Ciências·M C Diamond
Jan 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·José BorrellCarmen Guaza
Nov 15, 2002·Brain Research Bulletin·Michael E RhodesRobert T Rubin
Dec 21, 2002·The European Journal of Neuroscience·Lisa A TeatherRichard J Wurtman
Jun 1, 1959·Journal of Comparative and Physiological Psychology·G DAS, P L BROADHURST
Aug 1, 1964·The Journal of Comparative Neurology·M C DIAMONDM R ROSENZWEIG
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Emily E BelzMichael E Rhodes
Jan 27, 2004·Physiology & Behavior·Brian J Young, Christian J Cook
Sep 1, 1951·Canadian Journal of Psychology·M S RABINOVITCH, H E ROSVOLD
May 1, 2004·Journal of Neuroendocrinology·F MoncekD Jezova
Sep 10, 2004·The European Journal of Neuroscience·Giovanni LaviolaRoberta Pacifici
Oct 2, 2004·Neuropharmacology·Alessandro SaleLamberto Maffei
Jan 28, 2005·The European Journal of Neuroscience·Elodie Bruel-JungermanClaire Rampon

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Jan 31, 2012·Brain Research·Francisco MoraPedro Garrido
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