Enduring Effects of Paternal Deprivation in California Mice (Peromyscus californicus ): Behavioral Dysfunction and Sex-Dependent Alterations in Hippocampal New Cell Survival

Frontiers in Behavioral Neuroscience
Erica R GlasperTerrence J Hunter

Abstract

Early-life experiences with caregivers can significantly affect offspring development in human and non-human animals. While much of our knowledge of parent-offspring relationships stem from mother-offspring interactions, increasing evidence suggests interactions with the father are equally as important and can prevent social, behavioral, and neurological impairments that may appear early in life and have enduring consequences in adulthood. In the present study, we utilized the monogamous and biparental California mouse (Peromyscus californicus). California mouse fathers provide extensive offspring care and are essential for offspring survival. Non-sibling virgin male and female mice were randomly assigned to one of two experimental groups following the birth of their first litter: (1) biparental care: mate pairs remained with their offspring until weaning; or (2) paternal deprivation (PD): paternal males were permanently removed from their home cage on postnatal day (PND) 1. We assessed neonatal mortality rates, body weight, survival of adult born cells in the dentate gyrus of the hippocampus, and anxiety-like and passive stress-coping behaviors in male and female young adult offspring. While all biparentally-reared mice surviv...Continue Reading

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Software Mentioned

EthoVision ® XT
Peromyscus
GraphPad
Neurolucida
Adobe Photoshop Creative Cloud
SPSS
GraphPad Prism

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