Enemies and turncoats: bovine tuberculosis exposes pathogenic potential of Rift Valley fever virus in a common host, African buffalo (Syncerus caffer)

Proceedings. Biological Sciences
B R BeechlerAnna E Jolles

Abstract

The ubiquity and importance of parasite co-infections in populations of free-living animals is beginning to be recognized, but few studies have demonstrated differential fitness effects of single infection versus co-infection in free-living populations. We investigated interactions between the emerging bacterial disease bovine tuberculosis (BTB) and the previously existing viral disease Rift Valley fever (RVF) in a competent reservoir host, African buffalo, combining data from a natural outbreak of RVF in captive buffalo at a buffalo breeding facility in 2008 with data collected from a neighbouring free-living herd of African buffalo in Kruger National Park. RVF infection was twice as likely in individual BTB+ buffalo as in BTB- buffalo, which, according to a mathematical model, may increase RVF outbreak size at the population level. In addition, co-infection was associated with a far higher rate of fetal abortion than other infection states. Immune interactions between BTB and RVF may underlie both of these interactions, since animals with BTB had decreased innate immunity and increased pro-inflammatory immune responses. This study is one of the first to demonstrate how the consequences of emerging infections extend beyond dir...Continue Reading

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Citations

May 20, 2015·Acta Tropica·N le RoexP D van Helden
Jun 2, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·João QueirósChristian Gortazar
Oct 7, 2017·ILAR Journal·Melinda K RostalWilliam B Karesh
Jul 18, 2019·Proceedings. Biological Sciences·Hannah F TavalireAnna E Jolles
Jul 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Brianna R BeechlerAnna E Jolles
Jul 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Erin E GorsichAnna E Jolles

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