Energetics of endurance exercise in young horses determined by nuclear magnetic resonance metabolomics

Frontiers in Physiology
Margaux M LuckC Robert

Abstract

Long-term endurance exercise severely affects metabolism in both human and animal athletes resulting in serious risk of metabolic disorders during or after competition. Young horses (up to 6 years old) can compete in races up to 90 km despite limited scientific knowledge of energetic metabolism responses to long distance exercise in these animals. The hypothesis of this study was that there would be a strong effect of endurance exercise on the metabolomic profiles of young horses and that the energetic metabolism response in young horses would be different from that of more experienced horses. Metabolomic profiling is a powerful method that combines Nuclear Magnetic Resonance (NMR) spectrometry with supervised Orthogonal Projection on Latent Structure (OPLS) statistical analysis. (1)H-NMR spectra were obtained from plasma samples drawn from young horses (before and after competition). The spectra obtained before and after the race from the same horse (92 samples) were compared using OPLS. The statistical parameters showed the robustness of the model (R2Y = 0.947, Q2Y = 0.856 and cros-validated ANOVA p < 0.001). For confirmation of the predictive value of the model, a test set of 104 sample spectra were projected by the model, w...Continue Reading

Citations

Jul 22, 2017·Asian-Australasian Journal of Animal Sciences·Hyun-Jun JangByung-Wook Cho
Jan 3, 2019·Equine Veterinary Journal·L Nolazco SassotM G Sanz
Jun 9, 2020·Journal of Animal Physiology and Animal Nutrition·Dylan J KleinKenneth H McKeever
Feb 13, 2021·Metabolites·Anna HalamaTatiana Vinardell
May 18, 2021·Metabolomics : Official Journal of the Metabolomic Society·Violetta AruSøren Balling Engelsen
Jun 1, 2021·Frontiers in Veterinary Science·Lena BollingerHeidrun Gehlen

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR
PCA
deamination

Software Mentioned

house
Matlab code
R
Excel®

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