Energetics of inclusion-induced bilayer deformations

Biophysical Journal
C NielsenO S Andersen

Abstract

The material properties of lipid bilayers can affect membrane protein function whenever conformational changes in the membrane-spanning proteins perturb the structure of the surrounding bilayer. This coupling between the protein and the bilayer arises from hydrophobic interactions between the protein and the bilayer. We analyze the free energy cost associated with a hydrophobic mismatch, i.e., a difference between the length of the protein's hydrophobic exterior surface and the average thickness of the bilayer's hydrophobic core, using a (liquid-crystal) elastic model of bilayer deformations. The free energy of the deformation is described as the sum of three contributions: compression-expansion, splay-distortion, and surface tension. When evaluating the interdependence among the energy components, one modulus renormalizes the other: e.g., a change in the compression-expansion modulus affects not only the compression-expansion energy but also the splay-distortion energy. The surface tension contribution always is negligible in thin solvent-free bilayers. When evaluating the energy per unit distance (away from the inclusion), the splay-distortion component dominates close to the bilayer/inclusion boundary, whereas the compressio...Continue Reading

References

Jan 4, 1977·Biochimica Et Biophysica Acta·E Neher, H Eibl
Oct 19, 1978·Biochimica Et Biophysica Acta·B M HendryD A Haydon
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J C OwickiH M McConnell
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J C Owicki, H M McConnell
Oct 19, 1979·Biochimica Et Biophysica Acta·J R Elliott, D A Haydon
Jan 1, 1978·Biophysical Journal·O Alvarez, R Latorre
Jul 15, 1976·Biochimica Et Biophysica Acta·R M ServussW Helfrich
Nov 11, 1976·Biochimica Et Biophysica Acta·S Marcelja
Aug 1, 1991·Quarterly Reviews of Biophysics·M BloomO G Mouritsen
Apr 11, 1985·Biochimica Et Biophysica Acta·J R ElliottD A Haydon
Jun 12, 1985·Biochimica Et Biophysica Acta·P F Devaux, M Seigneuret
Jan 1, 1986·Faraday Discussions of the Chemical Society·S M GrunerR P Rand
Nov 1, 1973·Zeitschrift Für Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie·W Helfrich
Feb 18, 1972·Science·S J Singer, G L Nicolson
Mar 6, 1981·Biochimica Et Biophysica Acta·A JohannssonJ C Metcalfe
Oct 26, 1983·Biochimica Et Biophysica Acta·J R ElliottD A Haydon
Feb 16, 1984·Nature·P N Unwin, P D Ennis
Aug 1, 1984·Biophysical Journal·O G Mouritsen, M Bloom
Jun 1, 1982·Biophysical Journal·S B Hladky, D W Gruen
Oct 1, 1994·The Journal of General Physiology·J A Lundbaek, O S Andersen
Sep 6, 1994·Chemistry and Physics of Lipids·M F Brown
Jun 1, 1993·Biophysical Journal·J Song, R E Waugh
Mar 26, 1996·Biochemistry·J A LundbaekO S Andersen
Sep 1, 1996·Biophysical Journal·F Jähnig
Feb 4, 1998·Biophysical Journal·M GoulianA Libchaber
Jun 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·L MiaoH G Döbereiner
Apr 23, 1990·Physical Review Letters·E Evans, W Rawicz

❮ Previous
Next ❯

Citations

Jul 29, 2009·Analytical and Bioanalytical Chemistry·Claus Hélix Nielsen
Oct 1, 2009·The Journal of Membrane Biology·Jianjun PanJohn F Nagle
Sep 28, 2005·European Biophysics Journal : EBJ·Grace BranniganFrank L H Brown
Oct 26, 2013·European Biophysics Journal : EBJ·Jean-Pierre Duneau, James N Sturgis
Dec 7, 2006·Bulletin of Mathematical Biology·Liviu MovileanuAurel I Popescu
Aug 6, 2004·Bulletin of Mathematical Biology·A StéphanouP Tracqui
Jul 21, 2004·Colloids and Surfaces. B, Biointerfaces·Mariela E SánchezMaría A Perillo
Aug 29, 2003·Biophysical Journal·J A Szule, R P Rand
May 8, 1999·Biophysical Journal·R S Cantor
Jun 5, 2003·Pharmacology & Therapeutics·Alexander LeafGeorge E Billman
Aug 7, 2002·Comptes rendus biologies·Angélique Stéphanou, Philippe Tracqui
Jul 7, 2011·Quarterly Reviews of Biophysics·Frank L H Brown
Dec 15, 2010·The Journal of Physical Chemistry. B·Boris G DzikovskiJack H Freed
May 22, 2009·Nature·Rob PhillipsPierre Sens
Nov 27, 2009·Nature·Dmitriy KrepkiyKenton J Swartz
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jens A LundbaekOlaf S Andersen
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Per GreisenJens A Lundbæk
Apr 30, 2003·The Journal of General Physiology·Robyn L GoforthOlaf S Andersen
Dec 31, 2003·The Journal of General Physiology·Victor G RomanenkoIrena Levitan
Apr 16, 2008·The Journal of General Physiology·Jens A Lundbaek
May 14, 2008·The Journal of General Physiology·Seungho ChoeMichael Grabe
Jun 27, 2012·The Journal of General Physiology·Keith M CallenbergMichael Grabe
May 29, 2013·The Journal of General Physiology·Radda RusinovaOlaf S Andersen
Nov 27, 2009·Journal of the Royal Society, Interface·Jens A LundbaekOlaf S Andersen
Jul 9, 2010·The European Physical Journal. E, Soft Matter·R De Vita, I W Stewart
Feb 1, 2007·Annual Review of Biophysics and Biomolecular Structure·Olaf S Andersen, Roger E Koeppe
Jan 5, 2008·Annual Review of Physical Chemistry·Frank L H Brown
May 8, 2007·PLoS Computational Biology·Tristan UrsellRob Phillips
Jul 7, 2011·PLoS Computational Biology·Diana MorozovaMatthias Weiss
May 23, 2013·PLoS Computational Biology·Christoph A Haselwandter, Rob Phillips
Nov 13, 2012·PloS One·Anne-Florence BitbolJean-Baptiste Fournier
Jun 1, 2008·Biointerphases·Benedict J Reynwar, Markus Deserno
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Boris Martinac, Owen P Hamill
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Heedeok Hong, Lukas K Tamm
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Paul Wiggins, Rob Phillips
Nov 12, 2014·The Journal of General Physiology·Karl F HeroldHugh C Hemmings
Jan 3, 2016·Biochimica Et Biophysica Acta·Gernot Guigas, Matthias Weiss
Nov 18, 2015·The Journal of General Physiology·Radda RusinovaOlaf S Andersen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.