PMID: 6375554Apr 1, 1984

Energetics of tetracycline transport into Escherichia coli

Antimicrobial Agents and Chemotherapy
M C Smith, I Chopra


The nature of energy coupling for the active transport of tetracycline into Escherichia coli was examined under conditions in which antibiotic uptake was directly compared with transport of proline (proton motive force dependent) and glutamine (phosphate bond dependent). Tetracycline transport was partially inhibited by osmotic shock and by exposure of bacteria to arsenate, two procedures which substantially reduced glutamine transport. Tetracycline transport was also partially inhibited in an uncB mutant (AN283) exposed to the uncoupler carbonyl cyanide-m-chlorophenyl hydrazone (CCCP) under conditions that inhibited proline transport. Taken together, these data indicate involvement of both phosphate bond hydrolysis and the proton motive force for the active transport of tetracycline into E. coli.


Jan 1, 1979·Annual Review of Biochemistry·J A DownieG B Cox
Dec 30, 1975·Molecular & General Genetics : MGG·M SoS Falkow
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May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·E A Berger
May 27, 1980·Biochimica Et Biophysica Acta·I C West
Jan 1, 1983·Antimicrobial Agents and Chemotherapy·M C Smith, I Chopra
Mar 13, 1980·Biochemical and Biophysical Research Communications·P R BallI Chopra
Sep 1, 1981·Antimicrobial Agents and Chemotherapy·L M McMurryS B Levy


Apr 1, 1985·Archives of Microbiology·M Argast, C F Beck
Jan 13, 2000·European Journal of Biochemistry·A SiglerM Niederweis
May 1, 1986·Antimicrobial Agents and Chemotherapy·R A Dixon, I Chopra
Jan 1, 1991·Antimicrobial Agents and Chemotherapy·A YamaguchiT Sawai
Oct 1, 2008·Journal of Phycology·Roberta J GarciaRenate Reimschuessel
Dec 24, 2005·The Journal of Antimicrobial Chemotherapy·Santiago Ramón-GarcíaEdda De Rossi

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