Energy and Protein Supplementation Does Not Affect Protein and Amino Acid Kinetics or Pregnancy Outcomes in Underweight Indian Women

The Journal of Nutrition
Pratibha DwarkanathFarook Jahoor

Abstract

In India, the prevalence of low birth weight is high in women with a low body mass index (BMI), suggesting that underweight women are not capable of providing adequate energy and protein for fetal growth. Furthermore, as pregnancy progresses, there is increased need to provide methyl groups for methylation reactions associated with the synthesis of new proteins and, unlike normal-BMI American women, low-BMI Indian women are unable to increase methionine transmethylation and remethylation rates as pregnancy progresses from trimester 1 to 3. This also negatively influences birth weight. The aim was to determine the effect of dietary supplementation with energy and protein from 12 ± 1 wk of gestation to time of delivery compared with no supplement on pregnancy outcomes, protein kinetics, and the fluxes of the methyl group donors serine and glycine. Protein kinetics and serine and glycine fluxes were measured by using standard stable isotope tracer methods in the fasting and postprandial states in 24 pregnant women aged 22.9 ± 0.7 y with low BMIs [BMI (in kg/m(2)) ≤18.5] at 12 ± 1 wk (trimester 1) and 30 ± 1 wk (trimester 3) of gestation. After the first measurement, subjects were randomly assigned to either receive the supplement ...Continue Reading

References

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Aug 13, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Sarah L Duggleby, Alan A Jackson
Sep 27, 2002·The American Journal of Clinical Nutrition·Sarah L Duggleby, Alan A Jackson
Dec 31, 2004·Asia-Pacific Journal of Public Health·P ChhabraO P Aggarwal
May 28, 2009·European Journal of Clinical Nutrition·P DwarkanathF Jahoor
Nov 27, 2009·The American Journal of Clinical Nutrition·Jaividhya DasarathySatish C Kalhan
Jan 22, 2010·The American Journal of Clinical Nutrition·Minerva M ThameFarook Jahoor
Jul 7, 2012·Paediatric and Perinatal Epidemiology·Aamer Imdad, Zulfiqar A Bhutta
Sep 25, 2012·Asia-Pacific Journal of Public Health·Pratibha DwarkanathAnura V Kurpad
Jan 30, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Anura V KurpadFarook Jahoor
Apr 25, 2013·American Journal of Physiology. Endocrinology and Metabolism·Christina KaoFarook Jahoor

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Citations

Jun 9, 2016·Molecular and Cellular Endocrinology·Satish C Kalhan
Apr 25, 2017·Annals of the New York Academy of Sciences·Zohra S LassiZulfiqar A Bhutta
Nov 2, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Vani SethiMark Hanson

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