PMID: 6165413Jun 1, 1981Paper

Energy barriers for passage of ions through channels. Exact solution of two electrostatic problems

Biophysical Chemistry
P C Jordan

Abstract

Exact solutions are given to two electrostatic problems relevant to ion permeation through pores in membranes. The first assesses the importance of the pore forming molecule as a dielectric shield. It is shown on the basis of structural and dielectric considerations alone (neglecting effects attributable to possible charge distribution at the interior surface of the pre-former) that the minimum electrostatic barrier for monovalent ion passage through a gramicidin-like channel is 11 kT. It is further shown that given favorable circumstances, dielectric shielding might dramatically reduce the barrier to ion passage through potassium channels. The second problem considers the error introduced by treating ions as point charges. It is shown that for structureless pores the point charge approximation introduces no meaningful error, even if the ratio of ion radius to pore radius is as great as 0.95.

References

Dec 30, 1975·Annals of the New York Academy of Sciences·V A Parsegian
Jan 1, 1973·The Journal of Membrane Biology·E Bamberg, P Läuger
May 20, 1959·The Journal of General Physiology·L J MULLINS
Aug 19, 1960·Science·H M

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Citations

Jan 1, 1983·The Journal of Membrane Biology·R Latorre, C Miller
Jan 1, 1991·The Journal of Membrane Biology·G Eisenman, O Alvarez
Jan 1, 1985·Progress in Biophysics and Molecular Biology·K CooperP Wolynes
Nov 1, 1992·Quarterly Reviews of Biophysics·M B Partenskii, P C Jordan
Aug 1, 1984·Quarterly Reviews of Biophysics·A Warshel, S T Russell
Dec 15, 2010·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Michael ZwolakMassimiliano Di Ventra
Nov 10, 2001·Annual Review of Biomedical Engineering·J M Nitsche
Oct 17, 2015·Nano Letters·Hajar Mamad-HemouchJuan Pelta
Nov 5, 1999·Biophysical Journal·S H ChungS Kuyucak
Jun 29, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·J ZhangB I Shklovskii
May 7, 2009·FEBS Letters·Parimal KarSiegfried Höfinger
Jun 1, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Dezsö BodaBob Eisenberg
Jun 28, 2019·Chemical Reviews·Emelie FloodToby W Allen
Jul 21, 2006·The Journal of Physical Chemistry. B·A G Cherstvy

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