PMID: 4905670Jan 1, 1970Paper

Energy coupling in the lactose transport system of Escherichia coli

Proceedings of the National Academy of Sciences of the United States of America
P T WongT H Wilson

Abstract

A mutant (ML 308-22) was isolated from Escherichia coli ML 308, which had lost the normal capacity to accumulate lactose analogs despite an increase in the membrane carrier activity. The exit of thiomethylgalactoside was much faster than normal, accounting for the inability of the cell to maintain high intracellular concentrations of galactosides. Growth of the mutant on lactose was normal at high concentrations of sugar and impaired at low concentrations. This transport defect appeared to be limited to the lactose transport system as D-fucose and alpha-aminoisobutyric acid uptake and accumulation were normal. It is inferred from the data that the mutant possessed a defect in the coupling of metabolic energy to lactose transport.

References

Apr 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·B Müller-HillW Gilbert
Sep 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·C F Fox, E P Kennedy
Sep 14, 1968·Journal of Molecular Biology·B M OhlssonJ R Beckwith
Mar 18, 1961·Biochimica Et Biophysica Acta· von HOFSTEN
Jan 27, 1964·Biochimica Et Biophysica Acta·A L KOCH
Dec 1, 1964·Analytical Biochemistry·R F ITZHAKI, D M GILL
May 4, 1965·Biochimica Et Biophysica Acta·L S PRESTIDGE, A B PARDEE
Jan 1, 1961·Cold Spring Harbor Symposia on Quantitative Biology·A NOVICK, T HORIUCHI

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Citations

Jan 1, 1982·The Journal of Membrane Biology·P B Gordon, M S Rubin
Dec 1, 1971·The Journal of Membrane Biology·A Kepes
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E PadanH R Kaback
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A Peterkofsky, C Gazdar
Oct 1, 1971·The Journal of Experimental Medicine·M F Tsan, R D Berlin
Dec 7, 1981·Biochimica Et Biophysica Acta·D M WilsonT H Wilson
Sep 1, 1972·Biochimica Et Biophysica Acta·J M Becker, H C Lichstein
Mar 17, 1972·Biochimica Et Biophysica Acta·T H Wilson, M Kusch
May 27, 1980·Biochimica Et Biophysica Acta·I C West
Feb 1, 1976·Kidney International·C R ScriverR R McInnes
Aug 25, 1977·Journal of Molecular Biology·V A Fried
Jun 1, 1972·Journal of Theoretical Biology·J YarivE Katchalski
Dec 1, 1970·Biochimica Et Biophysica Acta·P Hechtman, C R Scriver
Jan 23, 1973·Biochemical and Biophysical Research Communications·I C West, T H Wilson
Jan 1, 1985·Annals of the New York Academy of Sciences·B BieselerK Beyreuther
Jan 1, 1985·Annals of the New York Academy of Sciences·H R Kaback
Jan 1, 1980·Annals of the New York Academy of Sciences·G J KaczorowskiH R Kaback
Oct 23, 1972·Biochimica Et Biophysica Acta·K Olden, T H Wilson
Sep 30, 1970·Biochemical and Biophysical Research Communications·T H WilsonE R Kashket
Aug 7, 1996·Biochimica Et Biophysica Acta·M F Varela, T H Wilson
Aug 25, 1980·FEBS Letters·D M WilsonT H Wilson
Nov 1, 1977·European Journal of Biochemistry·H Sandermann
Sep 4, 2014·Journal of Bacteriology·Sasikiran PasupuletiMichael D Manson
Sep 1, 1971·Journal of Bacteriology· von Meyenburg Kaspar
Jun 1, 1972·Bacteriological Reviews·F M Harold
Feb 1, 1971·Journal of Bacteriology·M Crandall, A L Koch
Feb 1, 1972·Journal of Bacteriology·E R Kashket, T H Wilson

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