Energy dependence of cytosolic enzyme efflux from rat skeletal muscle

Clinica Chimica Acta; International Journal of Clinical Chemistry
J A West-JordanM J Jackson

Abstract

(1) A recirculating isolated superfused skeletal muscle preparation has been developed for the study of rat soleus muscles at physiological temperature using 31P Nuclear Magnetic Resonance (NMR). (2) This system has been used to study intracellular muscle high energy phosphate content and pH during experimental damage to the muscle induced by 2,4-dinitrophenol, deoxycholate and the calcium ionophore, A23187. (3) Results indicate that release of intracellular cytosolic enzymes from damaged skeletal muscle may be induced by phosphocreatine (PCr) and adenosine trisphosphate (ATP) depletion, but under certain circumstances intracellular enzymes can be released from skeletal muscle without any fall in muscle PCr or ATP content.

References

Jun 1, 1977·The Journal of Physiology·M J DawsonD R Wilkie
Jan 14, 1977·Science·C T BurtM Bárány
Feb 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D J TaylorG K Radda
Apr 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·M J JacksonR H Edwards
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Citations

Dec 16, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·J A West-JordanM J Jackson
Feb 28, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·M J JacksonR H Edwards
Nov 1, 1995·Neuromuscular Disorders : NMD·A McArdleM J Jackson
Mar 8, 2013·Journal of Hypertension·Inge OudmanLizzy M Brewster
Apr 17, 2013·Journal of the International Society of Sports Nutrition·Seung-Lyul OhWook Song
Mar 23, 2012·PloS One·Lizzy M BrewsterGert A van Montfrans
Nov 1, 2006·Circulation·Lizzy M BrewsterGert A van Montfrans
Mar 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anne FredstedTorben Clausen
Jan 23, 2018·The Journal of Clinical Hypertension·Lizzy M BrewsterGert A van Montfrans
Jan 23, 2018·The Journal of Clinical Hypertension·Roberto PisoniTibor Fülöp

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