Energy Drinks Induce Acute Cardiovascular and Metabolic Changes Pointing to Potential Risks for Young Adults: A Randomized Controlled Trial

The Journal of Nutrition
Maryam BasraiStephan C Bischoff

Abstract

Case reports suggest a link between energy drinks (EDs) and adverse events, including deaths. We examined cardiovascular and metabolic effects of EDs and mixtures providing relevant ingredients of EDs compared to a similarly composed control product (CP) without these components. This randomized, crossover trial comprised 38 adults (19 women, mean BMI 23 kg/m2, mean age 22 y). We examined effects of a single administration of a commercial ED, the CP, and the CP supplemented with major ED-ingredients at the same concentrations as in the ED. The study products were administered at 2 volumes, 750 or 1000 mL. Both volumes of the study products were acceptably tolerated with no dose-dependent effects on blood pressure (BP, primary outcome), heart rate, heart rate corrected duration of QT-segment in electrocardiography (QTc interval), and glucose metabolism. After ED consumption, 11% of the participants reported symptoms, in contrast to 0-3% caused by other study products. After 1 h, administration of an ED caused an increase in systolic BP (116.9 ± 10.4 to 120.7 ± 10.7 mmHg, mean ± SD, P < 0.01) and a QTc prolongation (393.3 ± 20.6 to 400.8 ± 24.1 ms, P < 0.01). Also caffeine, but not taurine or glucuronolactone, caused an increase ...Continue Reading

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Citations

Jan 16, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu-Syuan LuoIvan Rusyn
Feb 26, 2021·Journal of Electrocardiology·Isabel LasherasJavier Santabárbara
Mar 7, 2021·Nutrients·Jorge Gutiérrez-Hellín, David Varillas-Delgado
May 6, 2020·Internal Medicine Journal·Andrea PiccioniFrancesco Franceschi
May 18, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sébastien La VieilleAndrew D Krahn
Dec 23, 2021·Scientific Reports·Felipe Sampaio-JorgeBeatriz Gonçalves Ribeiro

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