PMID: 9665095Jul 17, 1998Paper

Energy expenditure, body composition, and glucose metabolism in lean and obese rhesus monkeys treated with ephedrine and caffeine

The American Journal of Clinical Nutrition
J J RamseyJ W Kemnitz

Abstract

The administration of ephedrine and caffeine (E+C) has been proposed to promote weight loss by increasing energy expenditure and decreasing food intake. We tested this hypothesis in six lean (4-9% body fat) and six mildly to moderately obese (13-44% body fat) monkeys studied during a 7-wk control period, an 8-wk drug treatment period, and a 7-wk placebo period. During the drug treatment period, the monkeys were given ephedrine (6 mg) and caffeine (50 mg) orally three times per day. At the end of each period, a glucose tolerance test was performed, energy expenditure was measured, and body composition was determined. Treatment with E+C resulted in a decrease in body weight in the obese animals (P = 0.06). This loss in weight was primarily the result of a 19% reduction in body fat. Drug treatment also resulted in a decrease in body fat in the lean group (P = 0.05). Food intake was reduced by E+C only in the obese group (P < 0.05). Nighttime energy expenditure was increased by 21% (P < 0.03) in the obese group and 24% (P < 0.01) in the lean group with E+C treatment. Twenty-four-hour energy expenditure was higher in both groups during drug treatment. E+C did not produce systematic changes in glucoregulatory variables, whereas plasm...Continue Reading

Citations

Jan 27, 2006·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·E M R Kovacs, D J Mela
Jul 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kristel DiepvensMargriet S Westerterp-Plantenga
Feb 24, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·M Krajcovicová-KudláckováT Magálová
May 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C N BoozerT Meredith
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C N BoozerJ L Solomon
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·F L Greenway
Sep 10, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jan RozmanMartin Hrabě de Angelis
Jul 2, 2005·Journal of Psychiatric Practice·R P Brown, P L Gerbarg
Mar 29, 2002·Kidney International·Stevan P TofovicSheldon I Bastacky
Oct 27, 1999·Metabolism: Clinical and Experimental·J A GreenbergC N Boozer

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