Abstract
The tryptophan to arginine change in position 64 (Trp64Arg) polymorphism of the beta3-adrenergic receptor (beta3AR) gene has been associated with an increased prevalence of obesity, insulin resistance and type 2 diabetes. In this, decreased rates of energy expenditure and impaired insulin secretion could play a role. In 10 male twin pairs discordant for the Trp64Arg polymorphism, we examined insulin response to glucose by an oral glucose tolerance test (OGTT), a frequently sampled intravenous glucose tolerance test (FSIGT), body composition by the bioimpedance method, dual-energy X-ray absorptiometry scanning and energy expenditure by indirect and direct calorimetry. Twins heterozygous for the Trp64Arg polymorphism showed significantly lower fat mass independent of the method used, and significantly lower fasting insulin and glucose concentrations compared with their homozygous wild-type co-twins. Correspondingly, insulin resistance and insulin secretion determined by homeostasis model assessment were significantly lower in twins carrying the Trp64Arg polymorphism. However, there were no significant differences in adiponectin levels, insulinogenic index assessed by OGTT, or insulin sensitivity, acute insulin response to glucose...Continue Reading
References
Jan 1, 1992·World Review of Nutrition and Dietetics·M Elia, G Livesey
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Nov 25, 1995·Lancet·T YoshidaM Kondo
Aug 10, 1995·The New England Journal of Medicine·J WalstonN Raben
Aug 10, 1995·The New England Journal of Medicine·E WidénL C Groop
Aug 10, 1995·The New England Journal of Medicine·K ClémentA D Strosberg
Mar 1, 1995·The Journal of Clinical Investigation·F LönnqvistP Arner
Jan 1, 1993·The Journal of Clinical Investigation·S KriefL J Emorine
Aug 1, 1996·Diabetes·S A UrhammerO Pedersen
Nov 1, 1996·The Journal of Clinical Investigation·J GagnonC Bouchard
Jul 17, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D B AllisonA Pietrobelli
Sep 5, 1998·Medical Engineering & Physics·P FaberL Garby
May 25, 1999·Metabolism: Clinical and Experimental·B OngphiphadhanakulG Puavilai
Nov 5, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·C ChristiansenH Beck-Nielsen
Dec 20, 2000·American Journal of Physiology. Endocrinology and Metabolism·K HojlundH Beck-Nielsen
Sep 21, 2001·Journal of Molecular Endocrinology·R PerfettiJ D Walston
Apr 12, 2003·Obesity Research·Jeremy WalstonEric T Poehlman
Citations
Feb 4, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshihiro IwamotoHiromi Rakugi
Mar 10, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ming YuanToshio Ogihara
Oct 3, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Yue Zhang, Chengye Ji
Oct 29, 2010·International Journal of Hypertension·Kazuko Masuo
Feb 6, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Gerusa E Milano-GaiNeiva Leite
Nov 7, 2019·Current Diabetes Reports·Manfred James Müller, Anja Bosy-Westphal
Sep 27, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Resul YılmazEmel Ensari
Sep 14, 2021·Frontiers in Endocrinology·Hai-Dan WangJing Dong
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity