Energy expenditure, body composition and insulin response to glucose in male twins discordant for the Trp64Arg polymorphism of the beta3-adrenergic receptor gene

Diabetes, Obesity & Metabolism
K HøjlundH Beck-Nielsen

Abstract

The tryptophan to arginine change in position 64 (Trp64Arg) polymorphism of the beta3-adrenergic receptor (beta3AR) gene has been associated with an increased prevalence of obesity, insulin resistance and type 2 diabetes. In this, decreased rates of energy expenditure and impaired insulin secretion could play a role. In 10 male twin pairs discordant for the Trp64Arg polymorphism, we examined insulin response to glucose by an oral glucose tolerance test (OGTT), a frequently sampled intravenous glucose tolerance test (FSIGT), body composition by the bioimpedance method, dual-energy X-ray absorptiometry scanning and energy expenditure by indirect and direct calorimetry. Twins heterozygous for the Trp64Arg polymorphism showed significantly lower fat mass independent of the method used, and significantly lower fasting insulin and glucose concentrations compared with their homozygous wild-type co-twins. Correspondingly, insulin resistance and insulin secretion determined by homeostasis model assessment were significantly lower in twins carrying the Trp64Arg polymorphism. However, there were no significant differences in adiponectin levels, insulinogenic index assessed by OGTT, or insulin sensitivity, acute insulin response to glucose...Continue Reading

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Citations

Feb 4, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshihiro IwamotoHiromi Rakugi
Mar 10, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ming YuanToshio Ogihara
Oct 3, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Yue Zhang, Chengye Ji
Oct 29, 2010·International Journal of Hypertension·Kazuko Masuo
Feb 6, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Gerusa E Milano-GaiNeiva Leite
Nov 7, 2019·Current Diabetes Reports·Manfred James Müller, Anja Bosy-Westphal
Sep 27, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Resul YılmazEmel Ensari
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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