PMID: 2507030Aug 19, 1989Paper

Energy expenditure in children with type I diabetes: evidence for increased thermogenesis

BMJ : British Medical Journal
M J MüllerP Hürter

Abstract

The aim of the study was to assess whether increased energy expenditure causes the negative energy balance (tissue catabolism) commonly seen in children with insulin dependent (type I) diabetes. Resting metabolic rate and thermogenesis induced by adrenaline were measured in five healthy children and 14 children with type I diabetes who were all free of clinical signs of late complications of diabetes mellitus but differed in their degree of glycaemic control (in eight glycated haemoglobin concentration was less than 10% and in the six others greater than or equal to 10%). When compared with the control subjects children with type I diabetes had normal resting metabolic rates but their urinary nitrogen excretion was significantly raised (11.5 (SD 5.4) mg/min in those with glycated haemoglobin concentration less than 10%, 11.6 (5.2) mg/min in those with concentration greater than or equal to 10% v 5.4 (3.0) mg/min in control subjects). During the infusion of adrenaline the diabetic children showed a threefold and sustained increase in thermogenesis and disproportionate increases in the work done by the heart, in lipid oxidation rate, and in plasma concentrations of glucose, free fatty acids, and ketone bodies. The increased therm...Continue Reading

References

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Jul 1, 1984·The Journal of Clinical Investigation·M J MüllerH J Seitz

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Citations

Sep 1, 1996·Digestive Diseases and Sciences·G ZoliM J Farthing
Mar 29, 2005·European Journal of Nutrition·Anja Bosy-WestphalManfred J Müller
Jan 1, 1994·Archives of Disease in Childhood·A C ShoreJ E Tooke
Oct 7, 1989·BMJ : British Medical Journal·D MolnárG Soltész
Nov 1, 1993·Digestive Diseases and Sciences·M J MüllerF W Schmidt
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·O SelbergM J Müller
Dec 3, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A Bosy-WestphalM J Müller
Jan 10, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Harikrishna BandlaHarmeet Malhi
Apr 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A GrundM J Müller
May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J MüllerF W Schmidt
Nov 12, 2002·The British Journal of Nutrition·M J MüllerH Rieckert
Apr 9, 2005·The American Journal of Clinical Nutrition·Verena HaasManfred J Müller
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·K IllnerM J Müller
Jun 5, 1999·The American Journal of Clinical Nutrition·M J MüllerM P Manns
Mar 1, 1991·The American Journal of Physiology·M J MüllerF W Schmidt
Sep 1, 1990·The American Journal of Physiology·V PiolinoE Jéquier

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