Energy Expenditure of Dynamic Submaximal Human Plantarflexion Movements: Model Prediction and Validation by in-vivo Magnetic Resonance Spectroscopy

Frontiers in Bioengineering and Biotechnology
Daniel F B HaeufleNorman Stutzig

Abstract

To understand the organization and efficiency of biological movement, it is important to evaluate the energy requirements on the level of individual muscles. To this end, predicting energy expenditure with musculoskeletal models in forward-dynamic computer simulations is currently the most promising approach. However, it is challenging to validate muscle models in-vivo in humans, because access to the energy expenditure of single muscles is difficult. Previous approaches focused on whole body energy expenditure, e.g., oxygen consumption (VO2), or on thermal measurements of individual muscles by tracking blood flow and heat release (through measurements of the skin temperature). This study proposes to validate models of muscular energy expenditure by using functional phosphorus magnetic resonance spectroscopy (31P-MRS). 31P-MRS allows to measure phosphocreatine (PCr) concentration which changes in relation to energy expenditure. In the first 25 s of an exercise, PCr breakdown rate reflects ATP hydrolysis, and is therefore a direct measure of muscular enthalpy rate. This method was applied to the gastrocnemius medialis muscle of one healthy subject during repetitive dynamic plantarflexion movements at submaximal contraction, i.e....Continue Reading

References

Feb 15, 1978·Biological cybernetics·H Hatze
Apr 15, 1978·European Journal of Applied Physiology and Occupational Physiology·G Bolstad, A Ersland
Apr 1, 1985·Physiological Reviews·T Kodama
Mar 1, 1968·The Journal of Physiology·D R Wilkie
Jan 1, 1982·The Journal of General Physiology·M T Crow, M J Kushmerick
Jan 1, 1993·Biological cybernetics·A J van Soest, M F Bobbert
Sep 1, 1995·British Journal of Sports Medicine·S GrantT Aitchison
Jan 4, 1998·Journal of Magnetic Resonance·L Vanhamme Van Huffel S
Nov 27, 1999·Gait & Posture·R L Waters, S Mulroy
Jan 27, 2000·Medicine and Science in Sports and Exercise·D R Bassett, E T Howley
Apr 15, 2000·The Journal of Physiology·J González-AlonsoB Saltin
May 19, 2000·The Proceedings of the Nutrition Society·A HeerschapB Wieringa
Oct 6, 2000·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·H J HermensG Rau
Mar 26, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin MeyerspeerEwald Moser
May 15, 2003·Computer Methods in Biomechanics and Biomedical Engineering·Brian R UmbergerPhilip E Martin
Dec 16, 2003·Journal of Biomechanics·Lindsay J BhargavaFrank C Anderson
Jul 27, 2005·The Journal of Experimental Biology·G A Lichtwark, A M Wilson
Aug 5, 2005·Annals of Biomedical Engineering·Katherine R S HolzbaurScott L Delp
Nov 10, 2005·Public Health Nutrition·James A Levine
Jun 22, 2006·The Journal of Experimental Biology·Richard L Marsh, David J Ellerby
Dec 1, 2007·Biological cybernetics·Tobias SiebertReinhard Blickhan
Apr 2, 2010·Journal of the Royal Society, Interface·Brian R Umberger
Aug 4, 2010·The Journal of Physiology·C J BarclayN A Curtin
Jan 6, 2011·Exercise and Sport Sciences Reviews·Brian R Umberger, Jonas Rubenson
Nov 11, 2011·Proceedings. Biological Sciences·Ross H MillerGraham E Caldwell
Mar 1, 2013·Journal of Biomechanical Engineering·Matthew MillardScott L Delp
Sep 10, 2013·Pflügers Archiv : European journal of physiology·D B Lewis, C J Barclay
Mar 13, 2014·Journal of Biomechanics·D F B HaeufleS Schmitt
Apr 8, 2014·Medical Engineering & Physics·Kevin TschiescheJürgen R Reichenbach
Apr 2, 2015·Nature·Steven H CollinsGregory S Sawicki
Apr 17, 2015·Comprehensive Physiology·C J Barclay
Aug 22, 2015·Computer Methods in Biomechanics and Biomedical Engineering·Stefan HochsteinFrantišek Maršík
Sep 30, 2015·Computational and Mathematical Methods in Medicine·Robert RockenfellerThomas Götz
Jul 21, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Norman StutzigTobias Siebert

❮ Previous
Next ❯

Software Mentioned

Matlab Simulink
OsiriX MD
ODE23s
MATLAB script
jMRUI
Simulink

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Computer Methods in Biomechanics and Biomedical Engineering
Brian R UmbergerPhilip E Martin
American Journal of Preventive Medicine
Karin A PfeifferRussell R Pate
Metabolism: Clinical and Experimental
M J TothE T Poehlman
© 2021 Meta ULC. All rights reserved