Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral Sclerosis

Frontiers in Cellular Neuroscience
Yu-Ju LiuYijuang Chern

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease that is clinically characterized by progressive muscle weakness and impaired voluntary movement due to the loss of motor neurons in the brain, brain stem and spinal cord. To date, no effective treatment is available. Ample evidence suggests that impaired RNA homeostasis and abnormal energy status are two major pathogenesis pathways in ALS. In the present review article, we focus on recent studies that report molecular insights of both pathways, and discuss the possibility that energy dysfunction might negatively regulate RNA homeostasis via the impairment of cytoplasmic-nuclear shuttling in motor neurons and subsequently contribute to the development of ALS.

References

Nov 1, 1991·Acta Neurologica Scandinavica·L G GunnarssonE Strandman
Jan 1, 1996·The American Journal of Clinical Nutrition·E J KasarskisC J McClain
Jan 27, 1998·Neurology·N StamblerJ M Cedarbaum
Mar 28, 1998·The Journal of Biological Chemistry·M HallierF Moreau-Gachelin
Sep 25, 1999·Neurology·J C DesportP Couratier
Dec 28, 1999·Annual Review of Cell and Developmental Biology·D Görlich, U Kutay
Nov 18, 2000·The Journal of Physiology·D Ricquier, F Bouillaud
Dec 9, 2000·Developmental Neuroscience·A M GormanS Orrenius
Jul 27, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·J C DesportP Couratier
Aug 28, 2001·The American Journal of Clinical Nutrition·J C DesportP Couratier
Apr 10, 2002·Neurology·L LacomblezV Meininger
Oct 29, 2002·Annals of Neurology·Andoni Echaniz-LagunaEliane Lampert
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Luc DupuisJean-Philippe Loeffler
Aug 10, 2004·The Journal of Biological Chemistry·Yuko IkoKosuke Morikawa
Nov 9, 2004·Nature·Richard I GregoryRamin Shiekhattar
Apr 9, 2005·Journal of Neurochemistry·Szu-Yi ChouYijuang Chern
Dec 1, 2005·Journal of Cell Science·Ritsuko Fujii, Toru Takumi
Jul 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kelsey C Martin, R Suzanne Zukin
Jul 11, 2006·The Journal of Clinical Investigation·Yun Chau Long, Juleen R Zierath
Aug 16, 2006·Neuro-degenerative Diseases·Luc DupuisJean-Philippe Loeffler
Aug 16, 2006·Neuro-degenerative Diseases·Jean-Claude DesportPhilippe Couratier
Nov 23, 2006·Neuromolecular Medicine·Mark P MattsonSimonetta Camandola
Dec 5, 2006·Current Biology : CB·Atsushi YoshimuraToru Takumi
Apr 18, 2007·Journal of Lipid Research·Anissa FerganiJean-Philippe Loeffler
May 8, 2007·Molecular and Cellular Neurosciences·Michael J StrongChristen Shoesmith
Jun 1, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·I Ralph EdwardsAnne Kiuru
Jun 5, 2007·Neuroscience Letters·Janice RobertsonMichael J Strong
Dec 20, 2007·Journal of Neurochemistry·I-Fan WangC-K James Shen
Feb 23, 2008·Trends in Biochemical Sciences·Paul Anderson, Nancy Kedersha
Jun 19, 2008·Nature Clinical Practice. Neurology·Peter KühnleinAxel Riecker

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Citations

Sep 25, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S Vucic
May 2, 2018·Frontiers in Pharmacology·Ana M SebastiãoJoaquim A Ribeiro
Oct 17, 2018·International Journal of Molecular Sciences·Anna Konopka, Julie D Atkin
Aug 17, 2021·Frontiers in Cellular Neuroscience·Yu-Ju Liu, Yijuang Chern
May 28, 2021·CNS & Neurological Disorders Drug Targets·Marjan NikbakhtzadehGhorbangol Ashabi

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Methods Mentioned

BETA
antisense oligonucleotides

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