PMID: 15244841Jul 13, 2004Paper

Energy-landscape-model analysis for irreversibility and its pulse-width dependence in cells subjected to a high-intensity ultrashort electric pulse

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
R P JoshiS J Beebe

Abstract

We provide a simple, but physical analysis for cell irreversibility and apoptosis in response to an ultrashort (nanosecond), high-intensity electric pulse. Our approach is based on an energy landscape model for determining the temporal evolution of the configurational probability function p(q). The primary focus is on obtaining qualitative predictions of a pulse width dependence to apoptotic cell irreversibility that has been observed experimentally. The analysis couples a distributed electrical model for current flow with the Smoluchowski equation to provide self-consistent, time-dependent transmembrane voltages. The model captures the essence of the experimentally observed pulse-width dependence, and provides a possible physical picture that depends only on the electrical trigger. A number of interesting features are predicted.

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Citations

May 24, 2007·Apoptosis : an International Journal on Programmed Cell Death·Emily H HallStephen J Beebe
Jan 26, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C LiY Mi
Jul 13, 2007·Journal of Pharmaceutical Sciences·Joshua W Henshaw, Fan Yuan
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Sep 24, 2004·Physiological Measurement·Stephen J BeebeKarl H Schoenbach
Feb 1, 2013·Cell Biology International·Changjiang Ding, Liaofu Luo
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Nov 24, 2005·Bioelectromagnetics·Juergen F KolbKarl H Schoenbach
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May 16, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·R P JoshiK H Schoenbach
Apr 19, 2013·The Journal of Membrane Biology·Agnese DenziMicaela Liberti

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis