Energy loss due to paravalvular leak with transcatheter aortic valve implantation.

The Annals of Thoracic Surgery
Ali N AzadaniElaine E Tseng

Abstract

Mild to moderate paravalvular leaks commonly occur after transcatheter aortic valve (TAV) implantation. Current TAVs match and may exceed hemodynamic performance of surgically implanted bioprostheses based on pressure gradient and effective orifice area. However, these hemodynamic criteria do not account for paravalvular leaks. We recently demonstrated that TAV implantation within 23 mm Perimount bioprostheses (Edwards Lifesciences, Irvine, CA) yields similar hemodynamics to the 23 mm Perimount valve. However, mild paravalvular leakage was seen after TAV implantation. The present study quantifies energy loss during the entire cardiac cycle to assess the impact of TAV paravalvular leaks on the ventricle. Four TAVs designed to mimic the 23 mm SAPIEN valve (Edwards Lifesciences) were created. Transvalvular energy loss of 19, 21, and 23 mm Carpentier-Edwards bioprostheses were obtained in vitro within a pulse duplicator as a hemodynamic baseline (n = 4). The 23 mm TAVs were subsequently implanted within the 23 mm bioprostheses to assess energy loss due to paravalvular leak. The 23 mm bioprosthesis demonstrated the least energy loss (213.25 +/- 31.35 mJ) compared with the 19 mm (330.00 +/- 36.97 mJ, p = 0.003) and 21 mm bioprosthese...Continue Reading

References

Jan 1, 1995·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J Fisher
Jun 19, 1998·Clinical Cardiology·R MarajM N Kotler
Jan 24, 2008·Nature Clinical Practice. Cardiovascular Medicine·Ravinay BhindiOliver J Ormerod
Oct 29, 2008·The Journal of Thoracic and Cardiovascular Surgery·Cary W AkinsAjit P Yoganathan
Feb 3, 2009·American Heart Journal·Paul T L Chiam, Carlos E Ruiz
May 16, 2009·Journal of the American College of Cardiology·Alan Zajarias, Alain G Cribier
May 16, 2009·Journal of the American College of Cardiology·Marie-Annick ClavelJosep Rodés-Cabau
Jun 16, 2009·Journal of Biomechanics·Brandon R TravisFrancis Robicsek

❮ Previous
Next ❯

Citations

Apr 17, 2010·Interactive Cardiovascular and Thoracic Surgery·Ali N AzadaniElaine E Tseng
Dec 15, 2010·Future Cardiology·Ali N Azadani, Elaine E Tseng
Jun 19, 2013·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Danny DvirRon Waksman
May 25, 2013·The Annals of Thoracic Surgery·Lars G SvenssonMathew R Williams
Mar 13, 2013·The Journal of Thoracic and Cardiovascular Surgery·Joseph E BavariaHartzell V Schaff
Oct 4, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Alexandra GonçalvesJosé Luis Zamorano
Jun 28, 2011·The Annals of Thoracic Surgery·Ali N AzadaniElaine E Tseng
Nov 18, 2014·European Journal of Clinical Investigation·Luis CaballeroGonzalo de la Morena
Dec 22, 2010·The Annals of Thoracic Surgery·Daniel SilvaFriedrich-Christian Riess
May 7, 2013·Journal of the American College of Cardiology·Jan-Malte SinningNikos Werner
Nov 6, 2010·Journal of the American College of Cardiology·Mohammad A SherifGert Richardt
May 26, 2012·JACC. Cardiovascular Interventions·Fabian NietlispachMichael F Allard
Dec 24, 2013·Archives of Cardiovascular Diseases·Vincent AuffretHervé Le Breton
Dec 21, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Hiroki TateishiFabio S de Brito
Dec 22, 2011·Circulation. Cardiovascular Interventions·Ali N Azadani, Elaine E Tseng
Jun 20, 2020·Scientific Reports·Giorgia M BosiSilvia Schievano
Oct 12, 2013·Postgraduate Medicine·Vikas SinghClaudia A Martinez
Dec 21, 2016·Cardiovascular Engineering and Technology·Sharan RamaswamyFrank Scholl
Aug 1, 2019·Journal of Cardiovascular Translational Research·Paolo PeruzzoAndrea Colli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Thoracic and Cardiovascular Surgery
Cary W AkinsAjit P Yoganathan
Interactive Cardiovascular and Thoracic Surgery
Ali N AzadaniElaine E Tseng
© 2022 Meta ULC. All rights reserved