Energy metabolic pathways control the fate and function of myeloid immune cells

Journal of Leukocyte Biology
Amir A Al-KhamiAugusto C Ochoa

Abstract

The past decade has seen a significant interest in investigating the intracellular metabolism of cells of the immune system. This has increased the realization that immune cells endure metabolic reprogramming upon responding to pathogen-derived or inflammatory signals. More importantly, not only does this metabolic switch provide for the bioenergetic and biosynthetic demands but also it, in a highly specific manner, determines the cellular fate and function. In this review, we discuss the metabolic aspects that regulate the differentiation and function of myeloid cells, pivotal for both innate and adaptive immunity. The manipulation of these pathways can alter the function of these cells and therefore, could provide novel therapeutic approaches in cancer and other chronic inflammatory conditions.

Citations

Mar 24, 2018·Cellular & Molecular Immunology·Eslam MohamedPaulo C Rodriguez
Mar 20, 2018·Frontiers in Immunology·Viktor FlemingViktor Umansky
Jun 21, 2018·International Journal of Molecular Sciences·Yu-Lin SuMarcin Kortylewski
Sep 21, 2018·Frontiers in Immunology·Robin Maximilian AwadKarine Breckpot
Jun 11, 2020·Seminars in Immunopathology·Renata RamalhoMarkus Maeurer
Feb 10, 2021·Journal of Cellular Physiology·Hamid AriaMazdak Ganjalikhani-Hakemi
Dec 18, 2020·Frontiers in Cellular and Infection Microbiology·Md Aejazur RahmanAdrie J C Steyn
Mar 9, 2021·Frontiers in Immunology·Subhadip ChoudhuriNisha Jain Garg

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