PMID: 11925470Apr 2, 2002Paper

Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor

The Journal of Nutrition
Kyoko MiyasakaAkihiro Funakoshi

Abstract

Cholecystokinin (CCK) is an important gastrointestinal hormone as well as a neurotransmitter. Two types of CCK receptors, types A and B, have been identified. The CCK-A receptor is involved in satiety, food intake and behavior, whereas the B receptor is involved in anxiety. We recently produced CCK-A, -B and AB receptor knockout mice to study the role of these receptors in energy metabolism. Daily energy intake and expenditure were significantly greater in CCK-BR(-/-) and CCK-AR(-/-)BR(-/-) mice than CCK-AR(-/-) and wild-type [CCK-AR(+/+)BR(+/+)] mice. Relative liver and kidney weights (g/kg body) were significantly greater in CCK-AR(-/-)BR(-/-) mice than in wild-type mice. Energy metabolism and energy turnover were increased in mice with a disruption of the CCK-BR gene, although the underlying mechanism is unknown.

Citations

Aug 5, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan WengChunmin C Lo
Nov 23, 2017·Frontiers in Physiology·Ryusuke YoshidaYuzo Ninomiya
Sep 26, 2019·Journal of Animal Physiology and Animal Nutrition·Zhaobin WangHuansheng Yang
Aug 3, 2002·Nature Reviews. Genetics·Gregory S Barsh, Michael W Schwartz
Jun 5, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shigeki NomotoKyoko Miyasaka
Jun 14, 2006·Developmental Psychobiology·Timothy H Moran, Sheng Bi
Dec 1, 2006·The Journal of Physiological Sciences : JPS·Chihiro SakuraiKyoko Miyasaka
Dec 9, 2004·The American Journal of Clinical Nutrition·Virginie Van WymelbekeDaniel Rigaud
Nov 2, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James E BlevinsKozo Matsumoto
Oct 1, 2007·Expert Opinion on Drug Discovery·Ap Russ, J Grosse
Sep 13, 2006·The European Journal of Neuroscience·Hui ChenMargaret J Morris
Nov 9, 2005·The Japanese Journal of Physiology·Kyoko MiyasakaAkihiro Funakoshi
Feb 2, 2010·Gastroenterology·Chun-Min LoPatrick Tso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Japanese Journal of Physiology
Kyoko MiyasakaAkihiro Funakoshi
Alcoholism, Clinical and Experimental Research
Takehito OkuboSachio Matsushita
Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Kyoko MiyasakaAkihiro Funakoshi
© 2022 Meta ULC. All rights reserved