Energy metabolism in a matched model of radiation resistance for head and neck squamous cell cancer

Radiation Research
Jade MimsCristina M Furdui

Abstract

While radiation therapy is commonly used for treating cancer, radiation resistance can limit long-term control of the disease. In this study, we investigated the reprogramming of the energy metabolism in radiosensitive and radioresistant head and neck squamous cell carcinomas (HNSCC) using a preclinical matched model of radiation resistance. Our investigation found that radioresistant rSCC-61 cells: 1. They display increased glucose uptake and decreased fatty acid uptake; 2. They deviate from the classical Warburg effect by diverting the glycolytic flux into the pentose phosphate pathway; 3. They are more dependent on glucose than glutamine metabolism to support growth; 4. They have decreased mitochondrial oxidative phosphorylation; 5. They have enhanced fatty acid biosynthesis by increasing the expression of fatty acid synthase; and 6. They utilize endogenous fatty acids to meet the energy demands for proliferation. Inhibition of fatty acid synthase with orlistat or FASN siRNA resulted in increased cytotoxicity and sensitivity to radiation in rSCC-61 cells. These results demonstrate the potential of combination therapy using radiation and orlistat or other inhibitors of lipid and energy metabolism for treating radiation resist...Continue Reading

References

Apr 1, 1996·International Journal of Radiation Oncology, Biology, Physics·B K MohantiV Jain
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
May 19, 2000·British Journal of Cancer·C MothersillC B Seymour
Feb 24, 1956·Science·O WARBURG
Dec 28, 2005·Seminars in Radiation Oncology·Paul M Harari, Shyhmin Huang
Feb 10, 2006·The New England Journal of Medicine·James A BonnerK Kian Ang
Jun 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arlene A ForastiereJennifer R Grandis
Jul 15, 2006·Cell·Karim BensaadKaren H Vousden
Dec 16, 2006·Current Molecular Medicine·Patries M Herst, Michael V Berridge
Apr 5, 2007·Nature Protocols·Vanicha Vichai, Kanyawim Kirtikara
May 8, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Renzo Corvò
Jul 4, 2007·The Journal of Cell Biology·Mariia YunevaYuri Lazebnik
Sep 21, 2007·Nature Reviews. Cancer·Javier A Menendez, Ruth Lupu
Jan 8, 2008·Cell Metabolism·Ralph J DeBerardinisCraig B Thompson
Mar 7, 2008·The New England Journal of Medicine·Arlene ForastiereKian Ang
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Markus RalserHans Lehrach
Nov 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·David R WiseCraig B Thompson
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Sep 11, 2009·The Biochemical Journal·Bradford G HillVictor M Darley-Usmar
Dec 17, 2009·Journal of Cancer Research and Therapeutics·B S DwarakanathViney Jain
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Frank WeinbergNavdeep S Chandel
Aug 12, 2010·Endocrine-related Cancer·Jennifer F Barger, David R Plas
Jan 25, 2011·Nature Reviews. Cancer·Rob A CairnsTak W Mak
Feb 8, 2011·Antioxidants & Redox Signaling·Si JinPin-Lan Li
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 22, 2011·Nature Reviews. Cancer·Willem H KoppenolChi V Dang
Oct 4, 2011·Journal of Proteome Research·Bagganahalli S SomashekarAyyalusamy Ramamoorthy
Feb 22, 2012·Seminars in Cell & Developmental Biology·Dania Daye, Kathryn E Wellen
Mar 20, 2012·Annals of Diagnostic Pathology·Bruno Augusto Benevenuto de AndradeAlbina Altemani
Mar 24, 2012·Cancer Cell·Patrick S Ward, Craig B Thompson
Jun 30, 2012·The International Journal of Biochemistry & Cell Biology·Pratima TripathiAyyalusamy Ramamoorthy
Dec 5, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu-Chien KaoChien-Feng Li
Dec 25, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jonathan M BernsteinJarrod J Homer
Sep 4, 2013·The Journal of Clinical Investigation·Christopher T HensleyRalph J DeBerardinis
Jan 3, 2014·Antioxidants & Redox Signaling·Julie A ReiszCristina M Furdui
Mar 7, 2014·Antioxidants & Redox Signaling·Nidhi BansalCristina M Furdui

❮ Previous
Next ❯

Citations

May 12, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Xiaofei ChenCristina M Furdui
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li YanLuo Guo
Aug 2, 2017·Antioxidants & Redox Signaling·Joshua E LewisMelissa L Kemp
Nov 9, 2017·Antioxidants & Redox Signaling·Xiaofei ChenCristina M Furdui
May 4, 2018·Expert Opinion on Investigational Drugs·Alejandro Schcolnik-CabreraAlfonso Dueñas-González
Feb 19, 2019·Oncotarget·Colin Rae, Robert J Mairs
Nov 9, 2016·Oncotarget·Jiang-Tao Zhong, Shui-Hong Zhou
Aug 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Philippe MarchettiJérôme Kluza
Apr 2, 2020·Frontiers in Pharmacology·Debora GrassoPierre Sonveaux
Aug 23, 2020·Cancers·Christopher M WrightNicole L Simone
Sep 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chee Wai Fhu, Azhar Ali
Oct 26, 2018·Frontiers in Genetics·Ovidiu Dan IancuJacob Raber
Nov 21, 2018·Frontiers in Oncology·Esther A Zaal, Celia R Berkers
Nov 22, 2019·Frontiers in Oncology·Sina Dadgar, Narasimhan Rajaram
Aug 17, 2019·International Journal of Molecular Sciences·Yi-Ta HsiehWan-Chun Li
Mar 27, 2020·Frontiers in Oncology·Maria Andrea DesbatsMonica Montopoli
Oct 8, 2020·International Journal of Molecular Sciences·Dimitrios KorentzelosAlan Wells
Jun 28, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Benjamin ChevalierAlexandre Escande
Dec 20, 2020·Biology·Nicolas GermainPhilippe Marchetti
Aug 17, 2020·Life Sciences·Vaishali ChandelDhruv Kumar
Nov 7, 2017·The American Journal of Pathology·Rosemarie KruparAndrew G Sikora
Jun 15, 2021·Frontiers in Immunology·Khalil KhalafMariusz Kaczmarek
Aug 22, 2021·Nature Reviews. Cancer·Andrew J HoyLisa M Butler
Dec 29, 2021·Molecular Carcinogenesis·Graham H ReadAparna H Kesarwala

❮ Previous
Next ❯

Methods Mentioned

BETA
proteomic profiling
Transfections
Assay
transfection

Software Mentioned

XF
LSM image browser
SigmaPlot
Excel
ImageJ

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.