Energy partitioning between fat and bone mass is controlled via a hypothalamic leptin/NPY relay.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Nicola J LeeHerbert Herzog

Abstract

Maintaining energy balance is important to ensure a healthy organism. However, energy partitioning, coordinating the distribution of sufficient energy to different organs and tissues is equally important, but the control of this process is largely unknown. In obesity, an increase in fat mass necessitates the production of additional bone mass to cope with the increase in bodyweight and processes need to be in place to communicate this new weight bearing demand. Here, we investigate the interaction between leptin and NPY, two factors critically involved in the regulation of both energy metabolism and bone mass, in this process. We assessed the co-localization of leptin receptors on NPY neurons using RNAScope followed by a systematic examination of body composition and energy metabolism profiling in male and female mice lacking leptin receptors specifically in NPY neurons (Leprlox/lox;NPYCre/+). The effect of short-term switching between chow and high-fat diet was also examined in these mice. We uncovered that leptin receptor expression is greater on a subpopulation of NPY neurons in the arcuate that do not express AgRP. We further show that Leprlox/lox;NPYCre/+ mice exhibit significantly increased adiposity while bone mass is di...Continue Reading

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Citations

Jul 14, 2020·Journal of Pineal Research·Yuying LiJie Yin
Jul 27, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Gashaw DessieMeseret Derbew Molla

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Methods Mentioned

BETA
affinity purification
PCR

Software Mentioned

Prism
SPSS Statistics
GraphPad
RNAScope

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