PMID: 9430597Jan 31, 1998Paper

Energy restriction and zinc deficiency impair the functions of murine T cells and antigen-presenting cells during gastrointestinal nematode infection

The Journal of Nutrition
H N ShiK G Koski

Abstract

This study examined whether the impaired immune responses in zinc deficient- and/or energy-restricted mice exposed to a challenge infection of Heligmosomoides polygyrus might be associated with reduced numbers of spleen cells, altered proportions of spleen cell subpopulations and/or altered function of the T cells or antigen-presenting cells (APC). Female BALB/c mice were given free access to either a zinc-sufficient (60 mg zinc/kg diet, Zn+) or a zinc-deficient diet (0.75 mg zinc/kg diet, Zn-) or were pair-fed (PF) the zinc-sufficient diet. Significant differences in parasite burdens were observed. Worm numbers were lowest in Zn+ mice, intermediate in the PF mice and highest in the Zn- mice, showing that both zinc deficiency and energy restriction reduced protective immunity against the gastrointestinal nematode H. polygyrus. Although the absolute numbers of spleen cells were reduced in both Zn- and energy-restricted (PF) mice, neither deficiency altered the phenotypic distribution of the subpopulations of positive marker cells in the spleen. In vitro functional assays using a 1:1 ratio of APC:T cells showed that T-cell proliferation in response to parasite antigen (Ag) was impaired by a dietary effect of zinc deficiency on T ...Continue Reading

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Citations

Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·A Van Gossum, J Neve
May 26, 2001·Annual Review of Nutrition·K G Koski, M E Scott
Nov 17, 2007·The Journal of Infectious Diseases·E van RietM Yazdanbakhsh
Jun 1, 2000·Nutrition Research Reviews·P C Calder, A A Jackson
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·R IngK G Koski
Dec 18, 2001·Experimental Biology and Medicine·W FanH Takeuchi
Jan 28, 2005·Experimental Biology and Medicine·Tirang R Neyestani, Bill Woodward
Dec 15, 2007·Journal of Nutritional Science and Vitaminology·Junichi MatsumotoKiyoshi Ebihara
Apr 30, 2009·Journal of Leukocyte Biology·Tolunay B AydemirRobert J Cousins
Jun 24, 2011·The Journal of Nutrition·Mohammad T K SharkarRubhana Raqib
Oct 24, 2012·Population Health Management·Jen-Yin ChenMiao-Lin Hu
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Lorraine Lanningham-FosterRobert J Cousins
Feb 9, 2005·The American Journal of Clinical Nutrition·Muhammad J RahmanRubhana Raqib
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D M Kristan, K A Hammond
May 10, 2000·The Journal of Nutrition·P J FrakerT L Vollmer
Feb 24, 2009·British Poultry Science·Y M BaoK Bruerton
Apr 21, 2010·European Journal of Immunology·Bart EvertsMaria Yazdanbakhsh
Jun 11, 2004·Annual Review of Nutrition·Pamela J Fraker, Louis E King
Jun 29, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R WeindruchS R Spindler
Oct 19, 2010·The Journal of Veterinary Medical Science·Keiko HamaguchiSoichi Imai
Jan 27, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Shigeru MiyataDaizo Ihaku
May 6, 2003·The Journal of Nutrition·Robert J CousinsJeffrey A Bobo
Nov 2, 1999·Biochemical and Biophysical Research Communications·K G KoskiM E Scott

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