Energy restriction only slightly influences protein metabolism in obese rats, whatever the level of protein and its source in the diet

International Journal of Obesity : Journal of the International Association for the Study of Obesity
L ChevalierClaire Gaudichon

Abstract

High protein (HP) diets during energy restriction have been studied extensively regarding their ability to reduce body fat and preserve lean body mass, but little is known about their effects on protein metabolism in lean tissues. To determine the effects of energy restriction and protein intake on protein anabolism and catabolism in rats. For 5 weeks, 56 male Wistar rats were fed an obesity induction (OI) diet . They were then subjected to a 40% energy restriction using the OI diet or a balanced HP diet for 3 weeks, whereas a control group was fed the OI diet ad libitum (n=8 per group). HP-restricted rats were divided into five groups differing only in terms of their protein source: total milk proteins, casein (C), whey (W), a mix of 50% C and W, and soy (n=8). The animals were then killed in the postprandial state and their body composition was determined. Protein synthesis rates were determined in the liver, gastrocnemius and kidney using a subcutaneous (13)C valine flooding dose. mRNA levels were measured for key enzymes involved in the three proteolysis pathways. Energy restriction, but not diet composition, impacted weight loss and adiposity, whereas lean tissue mass (except in the kidney) was not influenced by diet compo...Continue Reading

References

May 1, 1991·Metabolism: Clinical and Experimental·T P SteinC E Bodwell
Mar 1, 1984·The Journal of Clinical Investigation·L J HofferD E Matthews
Feb 1, 1995·Metabolism: Clinical and Experimental·H L KatzeffI Klein
Sep 1, 1994·The American Journal of Physiology·M W Lee, D L Severson
Dec 1, 1993·The American Journal of Clinical Nutrition·C N BoozerR L Atkinson
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y BoirieB Beaufrère
Jun 11, 1998·Mechanisms of Ageing and Development·M M ScrofanoA Taylor
Oct 20, 1999·JAMA : the Journal of the American Medical Association·M K SerdulaG W Heath
Feb 24, 2001·The Journal of Nutrition·C JeanD Tomé
May 26, 2001·Obesity Research·M R FreedmanE Kennedy
Feb 11, 2003·Physiology & Behavior·Ahmed BensaïdGilles Fromentin
Apr 22, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·N D LuscombeG Wittert
Jan 8, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M S Westerterp-PlantengaE M R Kovacs
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Frederick G HamelWilliam C Duckworth
May 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Magali LacroixJean-François Huneau
Aug 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul S MacLeanJames O Hill
Jan 6, 2005·JAMA : the Journal of the American Medical Association·Michael L DansingerErnst J Schaefer
Mar 25, 2005·The British Journal of Nutrition·Manuela P G M LejeuneMargriet S Westerterp-Plantenga
May 5, 2005·American Journal of Physiology. Endocrinology and Metabolism·Anne L FriedlanderAllen Cymerman
Jul 28, 2005·The Journal of Nutrition·Donald K LaymanRichard A Boileau
Aug 10, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J T DourmashkinS F Leibowitz
Feb 14, 2006·The American Journal of Clinical Nutrition·James W KriegerBobbi Langkamp-Henken
Dec 5, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aude ZangarelliStéphane Walrand
Jan 17, 2007·Metabolism: Clinical and Experimental·James W AndersonAaron Tabor
Aug 2, 2007·Rejuvenation Research·Stephanie E WohlgemuthWilliam A Dunn
Jun 6, 2008·Mechanisms of Ageing and Development·Feng LiJeffrey N Keller
Aug 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Russell T HeppleSataro Goto
Jan 21, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M ClaessensW H M Saris
Feb 28, 2009·The New England Journal of Medicine·Frank M SacksDonald A Williamson
Oct 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laure ChevalierClaire Gaudichon

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Citations

Sep 27, 2012·American Journal of Physiology. Endocrinology and Metabolism·Guillaume KraftMary Courtney Moore
Sep 14, 2016·The British Journal of Nutrition·Guillaume GalmicheDominique Hermier
Nov 7, 2013·Inflammatory Bowel Diseases·Xinxin LiuFrançois Blachier
Jul 26, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andreas StengelYvette Taché

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