Energy state of the liver during short-term and exhaustive exercise in C57BL/6J mice

American Journal of Physiology. Endocrinology and Metabolism
Raul C CamachoDavid H Wasserman


A portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion that results in hepatic 5-aminoimidazole-4-carboxamide-1-beta-D-ribosyl-5-monophosphate (ZMP) concentrations of approximately 4 micromol/g liver increases hepatic glycogenolysis and glucose output. ZMP is an AMP analog that mimics the regulatory actions of this nucleotide. The aim of this study was to measure hepatic AMP concentrations in response to increasing energy requirements to test the hypothesis that AMP achieves concentrations during exercise, consistent with a role in stimulation of hepatic glucose metabolism. Male C57BL/6J mice (27.4+/- 0.4 g) were subjected to 35 min of rest [sedentary (SED), n=8], underwent short-term (ST, 35 min) moderate (20 m/min, 5% grade) exercise (n=8), or underwent treadmill exercise under similar conditions but until exhaustion (EXH, n=8). Hepatic AMP concentrations were 0.82+/- 0.05, 1.17+/- 0.11, and 2.52+/- 0.16 micromol/g liver in SED, ST, and EXH mice, respectively (P< 0.05). Hepatic energy charge was 0.66+/- 0.01, 0.58+/- 0.02, and 0.33+/- 0.22 in SED, ST, and EXH mice, respectively (P< 0.05). Hepatic glycogen was 11.6+/- 1.0, 8.8+/- 2.2, and 0.0+/- 0.1 mg/g liver in SED, ST, and EXH mice, respectively (P<...Continue Reading


Jun 1, 1991·The American Journal of Physiology·David H Wasserman, A D Cherrington
Sep 1, 1994·The American Journal of Physiology·C M BergerDavid H Wasserman
Apr 15, 1996·Archives of Biochemistry and Biophysics·N ErcanFrank Q Nuttall
Feb 1, 1996·The American Journal of Physiology·W W Winder, D Grahame Hardie
Feb 4, 1999·Journal of Applied Physiology·C L Carlson, W W Winder
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·Z P ChenBruce E Kemp
Oct 20, 2001·Journal of Applied Physiology·J W Rush, L L Spriet
Feb 21, 2002·The Journal of Biological Chemistry·Scott W NelsonHerbert J Fromm
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Nacide Ercan-FangFrank Q Nuttall
Dec 19, 2002·American Journal of Physiology. Endocrinology and Metabolism·Jorgen F P WojtaszewskiErik A Richter
Mar 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah L LongnusMichael F Allard
May 9, 2003·Journal of Applied Physiology·Jacinta BaldwinMark A Febbraio
Aug 28, 2003·Diabetes·Zhi-Ping ChenGlenn K McConell
Aug 28, 2003·The Journal of Biological Chemistry·Wu YinMorris J Birnbaum
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A RobergsDaryl Parker
Oct 21, 2004·The Journal of Biological Chemistry·Scot R KimballLeonard S Jefferson
Jul 28, 2005·American Journal of Physiology. Endocrinology and Metabolism·Raul C CamachoDavid H Wasserman


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Sep 6, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jonathan P LittleDavid C Wright
Jul 29, 2010·American Journal of Physiology. Endocrinology and Metabolism·Eric D BerglundDavid H Wasserman
Oct 9, 2008·American Journal of Physiology. Endocrinology and Metabolism·David H Wasserman
Aug 8, 2009·The Journal of Clinical Investigation·Eric D BerglundDavid H Wasserman
Dec 8, 2009·Journal of Lipid Research·Gabriele SchoiswohlRobert Zimmermann
Feb 26, 2016·Molecular Metabolism·Katarina MarcinkoGregory R Steinberg
Apr 14, 2016·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Bataa M El-KafouryAhmed E El-Sebaiee
Jul 22, 2008·Biochemical and Biophysical Research Communications·Ali K ReiterLeonard S Jefferson
Apr 14, 2015·Scientific Reports·L BiletV B Schrauwen-Hinderling
Dec 9, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jack A SargeantJames A King
Mar 31, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Beibei LuoYi-Ping Hu
Oct 20, 2018·Pflügers Archiv : European journal of physiology·Cora WeigertPeter Plomgaard
Feb 15, 2007·American Journal of Physiology. Endocrinology and Metabolism·Masako DoiFumiaki Yoshizawa
Jan 30, 2019·Medicine and Science in Sports and Exercise·Willem T PepplerDavid C Wright
Oct 25, 2011·Journal of Cellular Physiology·Kuo-Hui SuTzong-Shyuan Lee
May 23, 2012·Experimental Physiology·Lezi ERussell H Swerdlow
Dec 12, 2019·The Journal of Clinical Endocrinology and Metabolism·Chunxiu HuCora Weigert
Apr 29, 2020·American Journal of Physiology. Endocrinology and Metabolism·Timothy D AllertonJacqueline Stephens
Aug 28, 2020·Frontiers in Endocrinology·Steven K Malin, Nathan R Stewart
May 21, 2015·American Journal of Physiology. Endocrinology and Metabolism·Clinton M HasenourJamey D Young
Aug 29, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sandra C RodriguesSilvana Bordin

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