PMID: 8971495Jan 1, 1996Paper

Energy substrates, hormone responses and glucocorticoid binding in lymphocytes during intense physical exercise in humans following phosphocreatine administration

European Journal of Applied Physiology and Occupational Physiology
D V VorobievA I Grigoriev

Abstract

Eight healthy untrained male volunteers pedalled a cycle ergometer according to two exercise protocols: the first involved step-wise increasing physical exercise to maximal (MPE); the second involved prolonged (35 min) submaximal physical exercise (PPE) at 70% of the individual's maximal oxygen uptake. Each volunteer performed these exercise twice, following either an intravenous injection of phosphocreatine (PCr) or a placebo of an isotonic NaCl solution. Anaerobic threshold (AT) was determined from the point of departure of the ventilatory response from linearity and from the sudden increase in venous blood lactate concentrations during MPE. After exercise following placebo administration we observed increases in concentrations of blood substrates, plasma adrenocorticotropin (ACTH), growth hormone and cortisol and in the number of glucocorticoid receptors in lymphocytes without changes in the dissociation constant. Intravenous administration of PCr (starting 1 day before exercise) led to an increase in the total workload (on average by 5.8%) and in AT (on average by 6.8%) during MPE and to a better tolerance of exercise during PPE. Following PCr administration we observed lower blood lactate concentrations and different patte...Continue Reading

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Citations

Feb 3, 2012·Advances in Therapy·Ettore StrumiaGiuseppe D'Ambrosio
Dec 7, 2005·Medicine and Science in Sports and Exercise·Michael C PeyrebruneMary E Nevill
Jun 14, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Carine Smith, Kathryn H Myburgh
Jul 14, 2000·Physiological Reviews·M Wyss, R Kaddurah-Daouk
Aug 12, 2003·Journal of Applied Physiology·Katherine J GreenDavid G Rowbottom

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