Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus

Immunological Reviews
Michael S KrangelAbbas Hawwari

Abstract

V(D)J recombination proceeds according to defined developmental programs at T-cell receptor (TCR) and immunoglobulin loci as a function of cell lineage and stage of differentiation. Although the molecular details are still lacking, such regulation is thought to occur at the level of accessibility of chromosomal recombination signal sequences to the recombinase. The unique and complex organization of the TCRalpha/delta locus poses intriguing regulatory challenges in this regard: embedded TCRalpha and TCRdelta gene segments rearrange at distinct stages of thymocyte development, there is a highly regulated progression of primary followed by secondary rearrangements involving Jalpha segments, and there are important developmental constraints on V gene segment usage. The locus therefore provides a fascinating laboratory in which to explore the basic mechanisms underlying developmental control. We provide here a current view of cis-acting mechanisms that enforce the TCRalpha/delta locus developmental program, and we emphasize the unresolved issues that command the attention of our and other laboratories.

References

Jun 1, 1995·European Journal of Immunology·M Shimamura, S Ohta
Jul 1, 1995·The Journal of Experimental Medicine·H T PetrieS Mazel
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·X P Zhong, M S Krangel
Jul 1, 1997·European Journal of Immunology·I VilleyJ P de Villartay
Apr 29, 1998·European Journal of Immunology·E Jouvin-MarcheP N Marche
Oct 23, 1998·The Journal of Experimental Medicine·B P SleckmanF W Alt
Dec 16, 1998·Immunological Reviews·M S KrangelX P Zhong
Mar 19, 1999·Molecular and Cellular Biology·M L SikesE M Oltz
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·X P ZhongM S Krangel
Oct 16, 1999·Genes & Development·M Bulger, M Groudine
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·A Travers
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Weber-ArdenB Arden
May 10, 2000·Current Biology : CB·F McBlane, J Boyes
Oct 12, 2000·Nature·G Orphanides, D Reinberg
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Huang, O Kanagawa
Jul 4, 2001·Advances in Immunology·D G Hesslein, D G Schatz
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M GallagherE Jouvin-Marche
Aug 22, 2001·The Journal of Experimental Medicine·N YannoutsosM C Nussenzweig
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B D OrtizA Winoto
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S J ManciniE Jouvin-Marche
Nov 15, 2001·The EMBO Journal·D Chowdhury, R Sen
May 2, 2002·Cell·Craig H BassingFrederick W Alt

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Citations

Oct 5, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Michael L SikesJustin M Bradshaw
Mar 14, 2013·Nature Communications·Puspa ThapaVirginia Smith Shapiro
Sep 21, 2006·Nature Immunology·Jean-Pierre de Villartay
Aug 29, 2006·Nature Immunology·Iratxe Abarrategui, Michael S Krangel
Mar 6, 2007·Nature Immunology·Jane A SkokMeinrad Busslinger
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yu Nee LeeDavid Jung
Jan 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Wei GuoHong Wu
Aug 10, 2005·The Journal of Experimental Medicine·Abbas Hawwari, Michael S Krangel
Jun 23, 2010·The Journal of Experimental Medicine·Shan ZhaFrederick W Alt
Aug 11, 2010·The Journal of Experimental Medicine·Han-Yu Shih, Michael S Krangel
Jul 11, 2012·The Journal of Experimental Medicine·Laetitia PeaudecerfBenedita Rocha
Dec 5, 2012·Molecular and Cellular Biology·Gabriella VeraJean-Pierre de Villartay
Jan 15, 2014·Immunology and Cell Biology·Manuel WinterImmo Prinz
Jun 6, 2014·Immunogenetics·Jacques Robert, Eva-Stina Edholm
Jan 1, 2011·Genetics Research International·Beatriz Del BlancoCristina Hernández-Munain
Aug 20, 2014·The Journal of Experimental Medicine·Agata CieslakVahid Asnafi
Sep 11, 2010·Seminars in Immunology·Oleg Osipovich, Eugene M Oltz
Jun 15, 2007·European Journal of Immunology·Abdelbasset HamrouniAndreas Villunger
May 11, 2015·Cellular Immunology·Sabyasachi DasMax D Cooper
Jun 18, 2015·Nature Communications·Daisuke KamimuraMasaaki Murakami
Feb 25, 2015·Frontiers in Immunology·Hendrik ZieglerKarin Schilbach
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Abbas Hawwari, Michael S Krangel
Apr 14, 2009·Current Opinion in Immunology·Michael S Krangel
Aug 19, 2016·Proceedings of the National Academy of Sciences of the United States of America·Baojun ZhangYuan Zhuang
Jul 16, 2015·PloS One·Martina Kučerová-LevisohnBenjamin D Ortiz
Sep 21, 2007·The EMBO Journal·Iratxe Abarrategui, Michael S Krangel
Jul 2, 2011·Immunology·Taishan HuJosé Alberola-Ila
Mar 3, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jacques Robert, Yuko Ohta
May 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yong ChenXiao-Ping Zhong
Jul 16, 2020·The Journal of Experimental Medicine·Agata CieslakVahid Asnafi
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Juan CarabanaMichael S Krangel

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