Enfuvirtide plasma levels and injection site reactions using a needle-free gas-powered injection system (Biojector)

AIDS
Marianne HarrisJulio Sg Montaner

Abstract

To assess the use of the Biojector B2000 needle-free gas-powered injection system for subcutaneous administration of enfuvirtide in HIV-infected patients and to compare this system with standard needles and syringes with respect to ease of use, severity of injection site reactions (ISR), and enfuvirtide plasma levels. An observational study among 32 treatment-experienced HIV clinic patients receiving enfuvirtide. Adult patients were assessed before and after switching from standard needles to the Biojector for enfuvirtide administration. Patients used the Biojector for up to 24 weeks and rated ease of use from 0 (easy) to 3 (difficult). ISR were graded from 0 to 31 for signs and symptoms (erythema, induration, pruritus, nodules/cysts, ecchymosis), duration of individual lesions, and number of lesions. Plasma was collected pre-dose and 1 h post-dose for enfuvirtide measurement. The high-pressure liquid chromatography with tandem mass spectrometry method used was specific for enfuvirtide over its known plasma metabolite. Wilcoxon rank sum tests were used to compare needle-based and Biojector outcomes. The Biojector was rated as being significantly easier to use (P < 0.001) and reduced the occurrence of ISR compared with standard ...Continue Reading

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Citations

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Mar 4, 2006·AIDS·Marianne HarrisJulio S G Montaner
Sep 20, 2020·Vaccines·Johanna Hettinga, Robert Carlisle

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