Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

Proceedings of the National Academy of Sciences of the United States of America
Silke PaustHarvey Cantor

Abstract

Although there is considerable evidence that a subpopulation of regulatory CD4(+)CD25+ T cells can suppress the response of autoreactive T cells, the underlying molecular mechanism is not understood. We find that transmission of a suppressive signal by CD4CD25+ regulatory cells requires engagement of the B7 molecule expressed on target T cells. The response of T cells from B7-deficient mice is resistant to suppression in vitro, and these cells provoke a lethal wasting disease in lymphopenic mice despite the presence of regulatory T cells. Susceptibility of B7-deficient cells to suppression is restored by lentiviral-based expression of full-length, but not truncated, B7 lacking a transmembrane/cytoplasmic domain. Because expression of these B7 truncation mutants restores CD28-dependent costimulatory activity, these findings that indicate B7-based transmission of suppressive activity suggest new approaches to modifying autoimmune responses.

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H ReiserL M Nadler
Nov 14, 1997·Immunity·C B Thompson, J P Allison
Oct 10, 1998·Journal of Virology·T DullL Naldini
Mar 13, 2001·Annual Review of Immunology·J F Bach, L Chatenoud
Sep 21, 2001·Microbes and Infection·R S McHughA M Thornton
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J ErmannK Lejon
Nov 10, 2001·Nature Immunology·R S BystryA G Betz
Nov 28, 2001·Immunological Reviews·G C FurtadoJ J Lafaille
Nov 28, 2001·Immunological Reviews·B SinghF Powrie
Jul 3, 2002·Nature Reviews. Immunology·Ethan M Shevach
Aug 28, 2002·Immunity·Alison V CollinsSimon J Davis
Oct 9, 2002·Nature Immunology·Ursula GrohmannPaolo Puccetti
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 27, 2003·Nature Reviews. Immunology·Kathryn J Wood, Shimon Sakaguchi
Mar 27, 2003·Nature Reviews. Immunology·Jeffrey A Bluestone, Abul K Abbas
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian MottetFiona Powrie
Oct 28, 2003·Nature Immunology·Francesca FallarinoPaolo Puccetti
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patricia A TaylorBruce R Blazar
Apr 21, 2004·Nature Immunology·Dan HuHarvey Cantor

❮ Previous
Next ❯

Citations

Apr 25, 2009·Cellular and Molecular Life Sciences : CMLS·Creg J WorkmanDario A A Vignali
May 23, 2006·Medical Microbiology and Immunology·Christian BeckerHelmut Jonuleit
May 9, 2012·Journal of Clinical Immunology·Benedetta BonacciJames W Verbsky
Jan 19, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Joseph R Podojil, Stephen D Miller
Jan 1, 1990·Life Sciences·D M Barten, R F O'Dea
Oct 11, 2005·Autoimmunity Reviews·Enrico MaggiFrancesco Annunziato
Oct 10, 2007·Cell Research·Lauren E Mays, Youhai H Chen
Jun 3, 2005·Nature·Mitchell Kronenberg, Alexander Rudensky
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Cornelia M Weyand, Jörg J Goronzy
Sep 5, 2006·Nature Clinical Practice. Rheumatology·Ingo H Tarner, C Garrison Fathman
Dec 17, 2005·Nature Immunology·Philippe Bousso
Mar 24, 2005·Nature Immunology·Harald von Boehmer
Oct 18, 2005·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Jun 19, 2010·Nature Reviews. Immunology·Shimon SakaguchiDavid A Hafler
Mar 9, 2013·Nature Reviews. Immunology·Lieping Chen, Dallas B Flies
Oct 24, 2006·Bone Marrow Transplantation·N T Le, N Chao
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Christos TsatsanisPhilip N Tsichlis
Nov 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fabian Flores-BorjaMichael R Ehrenstein
Oct 28, 2009·The Journal of Biological Chemistry·Magis MandapathilTheresa L Whiteside
Mar 15, 2006·The Journal of Experimental Medicine·Alexander Y Rudensky, Daniel J Campbell
May 16, 2007·The Journal of Experimental Medicine·Silvia DeaglioSimon C Robson
Aug 30, 2008·The Journal of Experimental Medicine·Adrian ListonAlexander Y Rudensky
Feb 4, 2009·The Journal of Experimental Medicine·Randall H FriedlineCynthia A Chambers
Sep 10, 2009·International Immunology·Shimon SakaguchiTomoyuki Yamaguchi
Oct 12, 2005·Current Opinion in Hematology·Silvia GregoriMaria-Grazia Roncarolo
Sep 28, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Szu-Min HsiehShan-Chwen Chang
Oct 12, 2011·Current Opinion in Allergy and Clinical Immunology·James W Verbsky, Talal A Chatila
Apr 7, 2007·Current Opinion in Rheumatology·James W Verbsky
Sep 9, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Zoltán Fehérvari, Shimon Sakaguchi
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Nov 26, 2008·Circulation Research·Israel GotsmanAndrew H Lichtman
Nov 3, 2004·The Journal of Clinical Investigation·Zoltán Fehérvari, Shimon Sakaguchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.