Engagement of rat striatal neurons by cortical epileptiform activity investigated with paired recordings

Journal of Neurophysiology
Enrico BracciPaolo Calabresi

Abstract

The striatum is thought to play an important role in the spreading of epilepsy from cortical areas to deeper brain structures, but this issue has not been addressed with intracellular techniques. Paired recordings were used to assess the impact of cortical epileptiform activity on striatal neurons in brain slices. Bath-application of 4-amynopyridine (100 microM) and bicuculline (20 microM) induced synchronized bursts in all pairs of cortical neurons (< or = 5 mm apart) in coronal, sagittal, and oblique slices (which preserve connections from the medial agranular cortex to the striatum). Under these conditions, striatal medium spiny neurons (MSs) displayed a strong increased spontaneous glutamatergic activity. This activity was not correlated to the cortical bursts and was asynchronous in pairs of MSs. Sporadic, large-amplitude synchronous depolarizations also occurred in MSs. These events were simultaneously detected in glial cells, suggesting that they were accompanied by considerable increases in extracellular potassium. In oblique slices, cortically driven bursts were also observed in MSs. These events were synchronized to cortical epileptiform bursts, depended on non-N-methyl-D-aspartate (NMDA) glutamate receptors, and pers...Continue Reading

References

Apr 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·K Gale
Apr 1, 1992·Trends in Neurosciences·C R Gerfen
Mar 1, 1990·Trends in Neurosciences·B W Connors, M J Gutnick
Nov 1, 1991·The Journal of Physiology·Z G Jiang, R A North
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Jan 1, 1983·Progress in Brain Research·P S Goldman-Rakic
Jan 1, 1994·Progress in Neurobiology·A DepaulisC Marescaux
Jan 1, 1994·Progress in Brain Research·R D Traub, J G Jefferys
Nov 1, 1994·Journal of Neurophysiology·J Flores-HernándezJ Bargas
Jan 1, 1993·Progress in Brain Research·C J Wilson
Oct 29, 1993·Science·M SteriadeT J Sejnowski
Oct 1, 1995·British Journal of Pharmacology·M D CroningN R Newberry
Dec 1, 1995·Current Opinion in Neurobiology·A M Graybiel
May 20, 1998·Journal of Neurophysiology·J R Wickens, C J Wilson
May 5, 1999·Hippocampus·A BraginG Buzsáki
May 13, 1999·Nature Neuroscience·T Koós, J M Tepper
Jun 11, 1999·Neuroscience·P RedgraveK Gurney
Dec 22, 1999·Journal of Neurophysiology·M Steriade, F Amzica
Dec 22, 1999·Journal of Neurophysiology·F Amzica, M Steriade
Jan 13, 2000·Trends in Neurosciences·K K Wang
Feb 17, 2000·Trends in Neurosciences·P CalabresiG Bernardi
Apr 13, 2000·Brain Research. Brain Research Reviews·A Verkhratsky, C Steinhäuser
Aug 3, 2000·Journal of Anatomy·A R Crossman
Aug 3, 2000·Journal of Anatomy·J P BolamM D Bevan
Oct 29, 2000·Trends in Neurosciences·P CalabresiG Bernardi
May 10, 2001·Neuron·M J McKeown, J O McNamara
Apr 4, 2002·Journal of Neurophysiology·Enrico BracciPaolo Calabresi
Jun 4, 2002·International Review of Neurobiology·David A McCormick

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Citations

Mar 1, 2008·The Journal of Physiology·Craig Blomeley, Enrico Bracci
May 21, 2009·The European Journal of Neuroscience·Veronica GhiglieriPaolo Calabresi
Jun 21, 2005·Brain Research·Olivier DarbinDean K Naritoku
Dec 12, 2012·Neurobiology of Disease·Wilson YuDamian Seung-Ho Shin
Jan 25, 2008·Journal of Neurophysiology·Olivier Darbin, Thomas Wichmann

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