Engineered Airway Models to Study Liquid Plug Splitting at Bifurcations: Effects of Orientation and Airway Size

Journal of Biomechanical Engineering
Antonio CopploeHossein Tavana

Abstract

Delivery of biological fluids, such as surfactant solutions, into lungs is a major strategy to treat respiratory disorders including respiratory distress syndrome that is caused by insufficient or dysfunctional natural lung surfactant. The instilled solution forms liquid plugs in lung airways. The plugs propagate downstream in airways by inspired air or ventilation, continuously split at airway bifurcations to smaller daughter plugs, simultaneously lose mass from their trailing menisci, and eventually rupture. A uniform distribution of the instilled biofluid in lung airways is expected to increase the treatments success. The uniformity of distribution of instilled liquid in the lungs greatly depends on the splitting of liquid plugs between daughter airways, especially in the first few generations from which airways of different lobes of lungs emerge. To mechanistically understand this process, we developed a bioengineering approach to computationally design three-dimensional bifurcating airway models using morphometric data of human lungs, fabricate physical models, and examine dynamics of liquid plug splitting. We found that orientation of bifurcating airways has a major effect on the splitting of liquid plugs between daughter...Continue Reading

References

Aug 1, 1991·Journal of Biomechanical Engineering·K C HighS R Karl
Jul 9, 1998·Journal of Applied Physiology·F F Espinosa, R D Kamm
Jul 9, 1998·Journal of Applied Physiology·D HalpernJ B Grotberg
Jan 14, 1999·Journal of Applied Physiology·F F Espinosa, R D Kamm
May 8, 1999·Journal of Applied Physiology·E P IngenitoM Johnson
Jan 14, 2000·Journal of Biomechanical Engineering·G TanakaK Tanishita
Jul 12, 2001·Annual Review of Biomedical Engineering·J B Grotberg
Jan 11, 2002·Journal of Biomechanical Engineering·K J CassidyJ B Grotberg
Jan 17, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·David M KingRobert H Notter
May 20, 2003·Journal of Biomechanical Engineering·C Kleinstreuer, Z Zhang
Mar 26, 2005·Journal of Applied Physiology·Andrés J CalderónJoseph L Bull
Oct 27, 2005·Journal of Biomechanical Engineering·Y ZhengJ B Grotberg
Jan 4, 2006·Annals of Biomedical Engineering·Chris D Bertram, Donald P Gaver
Aug 16, 2006·Seminars in Respiratory and Critical Care Medicine·James F Lewis, Ruud A W Veldhuizen
Jan 20, 2007·Journal of Colloid and Interface Science·Cédric P OdyEmmanuel de Langre
Dec 19, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Hossein TavanaShuichi Takayama
Mar 16, 2011·Physics of Fluids·James B Grotberg
Jun 27, 2013·International Journal of Pharmaceutical Investigation·Amit GoelJaved Ali
Jul 23, 2013·Biomicrofluidics·Nadia Vertti QuinteroCharles N Baroud
Aug 29, 2013·Biotechnology and Bioengineering·David PetrakHossein Tavana
Sep 7, 2013·Journal of Biomechanical Engineering·Arun V Kolanjiyil, Clement Kleinstreuer
Jan 25, 2014·Journal of Applied Physiology·Eiichiro YamaguchiDonald P Gaver
Jul 30, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Ehsan AtefiHossein Tavana
Sep 30, 2014·Respiratory Physiology & Neurobiology·Clarissa MuereHubert V Forster
Nov 14, 2017·Journal of Biomechanical Engineering·Peshala P T GamageHansen A Mansy

❮ Previous
Next ❯

Citations

Mar 13, 2019·Annals of Biomedical Engineering·Antonio CopploeHossein Tavana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomaterial Engineering

Advances in biomaterial engineering have permitted the development of sophisticated drug-releasing materials with a biomimetic 3D support that allow a better control of the microenvironment of transplanted cells. Here is the latest research.

Related Papers

Respiratory Physiology & Neurobiology
David HalpernJ B Grotberg
Journal of Biomechanical Engineering
K J CassidyJ B Grotberg
© 2022 Meta ULC. All rights reserved