Engineered atherosclerosis-specific zinc ferrite nanocomplex-based MRI contrast agents

Journal of Nanobiotechnology
Rajneesh ChaudharyJagat Rakesh Kanwar

Abstract

Cardiovascular diseases are the most prevalent cause of morbidity and mortality affecting millions of people globally. The most effective way to counter cardiovascular complications is early diagnosis and the safest non-invasive diagnostic approach is magnetic resonance imaging (MRI). In this study, superparamagnetic ferrite nanoparticles doped with zinc, exhibiting highly enhanced saturation magnetization and T2 and computed tomography (CT) contrast were synthesized. These nanoparticles have been strategically engineered using bovine lactoferrin (Lf), polyethylene glycol (PEG), and heat shock protein (Hsp)-70 antibody specifically targeting atherosclerosis with potential therapeutic value. The nanocomplexes were further validated in vitro to assess their cytotoxicity, internalization efficiency, effects on cellular proliferation and were assessed for MRI as well as X-ray CT in ex vivo Psammomys obesus rat model. Optimized zinc doped ferrite nanoparticles (Zn0.4Fe2.6O4) with enhanced value of maximum saturation magnetization value on 108.4 emu/g and an average diameter of 24 ± 2 nm were successfully synthesized. Successfully incorporation with bovine lactoferrin, PEG and Hsp-70 (70 kDa) antibody led to synthesis of spherical na...Continue Reading

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Citations

Jan 15, 2019·Current Pharmaceutical Design·Virna M Martín GiménezWalter Manucha
Mar 2, 2019·Journal of Nanobiotechnology·Rajneesh ChaudharyJagat Rakesh Kanwar
Jul 19, 2018·Current Atherosclerosis Reports·Rajneesh ChaudharyJagat R Kanwar
Oct 5, 2020·International Journal of Biological Macromolecules·Esmail M El-Fakharany
Dec 21, 2021·Food & Function·Bing LiXiaomeng Liu

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Methods Mentioned

BETA
X-ray
Transmission
electrophoresis
Transmission electron microscopy
dynamic light scattering
confocal
flow cytometry
dissection
fluorescence microscopy

Software Mentioned

Vnmr

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