Engineered Chimeric Peptides as Antimicrobial Surface Coating Agents toward Infection-Free Implants

ACS Applied Materials & Interfaces
Hilal YaziciCandan Tamerler

Abstract

Prevention of bacterial colonization and consequent biofilm formation remains a major challenge in implantable medical devices. Implant-associated infections are not only a major cause of implant failures but also their conventional treatment with antibiotics brings further complications due to the escalation in multidrug resistance to a variety of bacterial species. Owing to their unique properties, antimicrobial peptides (AMPs) have gained significant attention as effective agents to combat colonization of microorganisms. These peptides have been shown to exhibit a wide spectrum of activities with specificity to a target cell while having a low tendency for developing bacterial resistance. Engineering biomaterial surfaces that feature AMP properties, therefore, offer a promising approach to prevent implant infections. Here, we engineered a chimeric peptide with bifunctionality that both forms a robust solid-surface coating while presenting antimicrobial property. The individual domains of the chimeric peptides were evaluated for their solid-binding kinetics to titanium substrate as well as for their antimicrobial properties in solution. The antimicrobial efficacy of the chimeric peptide on the implant material was evaluated i...Continue Reading

References

Feb 1, 1995·Antimicrobial Agents and Chemotherapy·S L HaynieB A Doele
Feb 1, 1996·Journal of Molecular Graphics·W HumphreyK Schulten
Jul 18, 2000·Antimicrobial Agents and Chemotherapy·C L FriedrichR E Hancock
Jun 19, 2001·Biological Chemistry·W van 't HofA V Amerongen
Jan 25, 2002·Nature·Michael Zasloff
Mar 5, 2003·Pharmacological Reviews·Michael R Yeaman, Nannette Y Yount
Sep 3, 2003·Nature Materials·Mehmet SarikayaFrançois Baneyx
Nov 20, 2003·Journal of the American Chemical Society·Ken-Ichi Sano, Kiyotaka Shiba
Mar 17, 2004·Peptides·Jon-Paul S Powers, Robert E W Hancock
Apr 9, 2004·The New England Journal of Medicine·Rabih O Darouiche
Feb 11, 2005·Nature Reviews. Microbiology·Kim A Brogden
Mar 10, 2005·Nano Letters·Ersin Emre OrenMehmet Sarikaya
Mar 23, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ken-Ichi SanoKiyotaka Shiba
Apr 14, 2005·Chemical Reviews·J Christopher LoveGeorge M Whitesides
May 17, 2005·Nature Materials·Archit B SanghviChristine E Schmidt
Dec 21, 2005·Biomaterials·Davide CampocciaCarla Renata Arciola
Jun 8, 2006·Biochimica Et Biophysica Acta·David I ChanHans J Vogel
Aug 29, 2006·Chemical Society Reviews·Evan M Hetrick, Mark H Schoenfisch
Dec 13, 2006·Nature Biotechnology·Robert E W Hancock, Hans-Georg Sahl
Dec 29, 2006·Small·Candan TamerlerMehmet Sarikaya
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Min LiMichael Otto
Jun 21, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Urartu Ozgur Safak SekerMehmet Sarikaya
Oct 27, 2007·Molecular Microbiology·Min LiMichael Otto
Jun 7, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Haibin ChenWoo-Seok Choe
Jan 28, 2009·Chemistry & Biology·Kai HilpertRobert E W Hancock
Jul 29, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lingzhou ZhaoZhifen Wu
Sep 9, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Tomohiro HayashiMasahiko Hara
Jan 22, 2010·Biopolymers·Candan TamerlerMehmet Sarikaya
Jul 6, 2010·Acta Biomaterialia·Dmitriy KhatayevichMehmet Sarikaya
Sep 8, 2010·Biotechnology Advances·Sagheer A Onaizi, Susanna S J Leong
Nov 9, 2010·Acta Biomaterialia·Fabíola CostaM Cristina L Martins
Jul 28, 2009·ACS Nano·Candan Tamerler, Mehmet Sarikaya
Nov 3, 2011·Journal of Biomedical Materials Research. Part a·Menghan MaRizhi Wang
Jan 12, 2012·ACS Nano·Christopher R SoMehmet Sarikaya
Apr 12, 2012·Journal of the Royal Society, Interface·Senem DonatanMustafa Urgen
May 9, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mehdi Kazemzadeh-NarbatRizhi Wang
Aug 21, 2013·Biomaterials·Davide CampocciaCarla Renata Arciola

❮ Previous
Next ❯

Citations

Jul 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annarita FalangaOlga Scudiero
Jul 11, 2018·Advanced Materials·Moran AmitNurit Ashkenasy
Oct 18, 2018·Advanced Healthcare Materials·Jinkyu LeeHeungsoo Shin
Mar 22, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Paulette SpencerCandan Tamerler
Jul 18, 2019·Journal of Dental Research·D G MoussaC Aparicio
Sep 26, 2019·Protein and Peptide Letters·Mithoor DivyashreeDebmalya Barh
Mar 19, 2020·Organic & Biomolecular Chemistry·Benjamin F HohlfeldArno Wiehe
Aug 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nicholas G FischerConrado Aparicio
Mar 1, 2016·Journal of Molecular and Engineering Materials·Cate WisdomCandan Tamerler
Jul 28, 2017·Journal of Oral Microbiology·Zhejun WangMarkus Haapasalo
Oct 4, 2017·Frontiers in Chemistry·Martijn RioolSebastian A J Zaat
Oct 25, 2017·Biotechnology and Bioengineering·Kristin RübsamUlrich Schwaneberg
Apr 13, 2018·Frontiers in Pharmacology·Anja PfalzgraffGünther Weindl
Jun 8, 2018·Advanced Science·Serena RigoCornelia G Palivan
Oct 24, 2017·Surface Innovations·Sarah Kay VanOostenCandan Tamerler
Oct 20, 2020·Critical Reviews in Biotechnology·Mehdi Kazemzadeh-NarbatAli Khademhosseini
Jan 27, 2021·Journal of Peptide Science : an Official Publication of the European Peptide Society·Zhou Ye, Conrado Aparicio
Feb 14, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Kang LiCynthia Kar Yung Yiu
Feb 1, 2019·Applied Sciences·Sheng-Xue XieCandan Tamerler
Mar 16, 2021·Molecular Oral Microbiology·John Yun NiuChun Hung Chu
Jun 11, 2021·BMC Musculoskeletal Disorders·Jian Wang, Liucai Wang
Jul 3, 2021·International Journal of Molecular Sciences·Esra YucaCandan Tamerler
Feb 2, 2018·ACS Chemical Biology·Jessica L AlexanderJ A Cowan
Mar 5, 2020·ACS Applied Materials & Interfaces·Abeer KarmiDanny Porath
Feb 6, 2020·ACS Applied Materials & Interfaces·Shuhao LiuMustafa Akbulut
Aug 20, 2021·Journal of Applied Biomaterials & Functional Materials·Aqsa ShahidMohsin Khurshid
Apr 10, 2021·ACS Applied Polymer Materials·Sheng-Xue XieCandan Tamerler
Jan 20, 2021·ACS Biomaterials Science & Engineering·Sudhir K SainiRajesh V Nair
May 30, 2020·ACS Biomaterials Science & Engineering·E Cate WisdomMalcolm L Snead
Oct 5, 2021·ACS Applied Materials & Interfaces·Li-Sheng WangVincent M Rotello

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.