Engineered drug-loaded cells and cell derivatives as a delivery platform for cancer immunotherapy.

Biomaterials Science
Lu Wang, Jinyao Liu

Abstract

Cancer immunotherapy, which provides durable clinical responses by restoring or boosting the patient's immune system to fight cancer, has become a promising strategy for cancer treatment. However, modest response rates and on-target off-tumor toxicity largely limit extensive implementation of this approach in clinical settings. Advances in drug delivery and combination with other cancer treatments are able to effectively promote the potency of cancer immunotherapy. Engineered natural particulates, such as cells and their derivatives, have been recently developed as prospective drug delivery systems that comprehensively combine genetic engineering, synthetic materials, and nanotechnology to enhance anticancer efficacy. Here, recent advances in improving cancer immunotherapy have been summarized with a focus on using functionalized intact cells and cell derivatives including cell membranes and extracellular vesicles as drug vehicles. The advantages and challenges of these unique systems have been further elucidated in terms of clinical translation. The results presented in this review would contribute to the development of advanced therapies for treating cancers.

References

Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G M IhlerF W Schnure
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rebecca IngMary M Stevenson
Sep 28, 2006·Experimental Dermatology·Lina ElzaoukJovan Pavlovic
Jan 2, 2009·Cancer Research·Jielin SunBao-Li Chang
Aug 13, 2009·Nature Reviews. Molecular Cell Biology·Paul Saftig, Judith Klumperman
Jun 17, 2010·Nature Reviews. Neurology·Dan ShlosbergAlon Friedman
Jan 25, 2011·Nature Reviews. Cancer·Laurie J Gay, Brunhilde Felding-Habermann
Mar 24, 2011·Cancer Research·Alyssa D Gregory, A McGarry Houghton
Mar 26, 2011·Nature Reviews. Immunology·John W SempleJohn Freedman
Jul 2, 2011·Nature Reviews. Drug Discovery·Jin-Wook YooSamir Mitragotri
Aug 9, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Divya SagarPooja Jain
Nov 25, 2011·Nature Reviews. Cancer·Melin J KhandekarBruce M Spiegelman
Jun 30, 2012·Science Translational Medicine·Samuel R DenmeadeJohn T Isaacs
Feb 20, 2013·The Journal of Cell Biology·Graça Raposo, Willem Stoorvogel
Feb 26, 2013·Nature Reviews. Immunology·Elzbieta Kolaczkowska, Paul Kubes
Jul 31, 2013·Immunity·Daniel S Chen, Ira Mellman
Jul 31, 2013·Immunity·Karolina Palucka, Jacques Banchereau
Sep 26, 2013·Nature Reviews. Cancer·James E Talmadge, Dmitry I Gabrilovich
Nov 10, 2013·Nature Medicine·Liling WanYibin Kang
Jan 28, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andrew RichesSimon Powis
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jonathan A CoppLiangfang Zhang
Sep 27, 2014·Chemical Reviews·Liang ChengZhuang Liu
Oct 17, 2014·Chemical Society Reviews·Nazir AhmadFrancis Verpoort
May 23, 2015·Theranostics·Songwei TanZhiping Zhang
Sep 17, 2015·Nature·Che-Ming J HuLiangfang Zhang
Oct 31, 2016·Advanced Drug Delivery Reviews·Carlos H VillaVladimir Muzykantov
Oct 30, 2016·Trends in Immunology·Alycia Gardner, Brian Ruffell
Nov 5, 2016·Nature Reviews. Drug Discovery·Francesc ArtigasAdam J Schwarz
Nov 8, 2016·Nature Nanotechnology·Nana Amponsah KyerematengDavid Pech
Dec 14, 2016·Cancer Cell·Annette BeckerDavid Lyden
Feb 6, 2017·Regenerative Biomaterials·Gretchen S SeldersGary L Bowlin
Dec 12, 2017·Accounts of Chemical Research·Lucas R ParentNathan C Gianneschi
Dec 15, 2017·Advanced Materials·Ashley V KrollLiangfang Zhang
Dec 28, 2017·Angewandte Chemie·Neville Compton
Jan 30, 2018·Nature Reviews. Drug Discovery·Amy Yip, Rachel M Webster
May 26, 2018·Nature Reviews. Clinical Oncology·Rong XuRichard J Simpson
Jul 10, 2018·Nature Biotechnology·Li TangDarrell J Irvine

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
FACS
ELISA
transfection

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Peter AbdouZhen Gu
Archives of Pharmacal Research
Md AsadujjamanJun-Pil Jee
Advances in Cancer Research
C Tilden HaganAndrew Z Wang
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Safiye AkkınErem Bilensoy
© 2021 Meta ULC. All rights reserved