Engineered heparins as new anticoagulant drugs.

Bioengineering & Translational Medicine
Deepika VaidyanathanRobert J Linhardt

Abstract

Heparin is an anionic polysaccharide that is widely used as a clinical anticoagulant. This glycosaminoglycan is prepared from animal tissues in metric ton quantities. Animal-sourced heparin is also widely used in the preparation of low molecular weight heparins that are gaining in popularity as a result of their improved pharmacological properties. The recent contamination of pharmaceutical heparin together with concerns about increasing demand for this life saving drug and the fragility of the heparin supply chain has led the scientific community to consider other potential sources for heparin. This review examines progress toward the preparation of engineered heparins through chemical synthesis, chemoenzymatic synthesis, and metabolic engineering.

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Nov 22, 2017·Applied Microbiology and Biotechnology·Hao-Miao ZhuJu-Zheng Sheng
Jan 10, 2018·Bioengineering & Translational Medicine·Pankaj Karande
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Dec 23, 2021·Science Advances·Richard KarlssonRebecca L Miller

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Methods Mentioned

BETA
sulfotransferases
membrane filtration
glycotransferase
GTases
glycosylation
gene knockout
glycotransferases

Software Mentioned

ePathBricks
ePathBrick

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