PMID: 12773119May 30, 2003Paper

Engineered IGF-I expression induces glandular enlargement in the murine prostate

The Journal of Endocrinology
Naoko Konno-TakahashiT Kitamura

Abstract

IGF-I has been implicated as a factor that may predispose one to prostate cancer and to benign prostatic hypertrophy (BPH). We established murine IGF-I transgenic mice under the control of rat probasin promoter and analysed the histology of the murine IGF-I-overexpressing prostate. Immunohistochemically, IGF-I was expressed in prostatic epithelial cells or basement membranes of the ventral, dorsal and lateral lobes in a line of IGF-I transgenic mice, but not in their control littermates. The anterior lobe did not express IGF-I. IGF-binding protein-3 (IGFBP-3), inhibitory to the mitogenic action of IGF-I, was detected in epithelial cells of prostatic ventral lobes, but not in those of the dorsal, lateral or anterior lobes of IGF-I transgenic mice. In controls, IGFBP-3 was not detected in epithelial cells of any prostatic lobe. Macroscopic prostatic size and the appearance of IGF-I transgenic mice were comparable with those of their control littermates of the same age. With a computed morphometric analysis, epithelial glands and intraglandular lumens in the prostatic lobes except the ventral lobe were smaller at 17 Months of age than at 14 Months both in IGF-I transgenic mice and controls. Glands and intraglandular lumens in the ...Continue Reading

Citations

Feb 10, 2010·Cancer Metastasis Reviews·Varinder JeetAparajita Khatri
May 16, 2009·Endocrinology·Jayoung KimMichael R Freeman
Apr 13, 2013·Endocrine-related Cancer·Xinyu WuZoran Culig
Jul 8, 2010·Tissue & Cell·Fábio MonticoValéria Helena Alves Cagnon
Jul 14, 2010·International Journal of Experimental Pathology·Leslie C PintoValéria H A Cagnon

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